- Original article
- Open Access
Computed tomography image quality of aortic stents in patients with aortic coarctation: a multicentre evaluation
European Radiology Experimental volume 2, Article number: 17 (2018)
Stents are commonly used to treat aortic coarctation. The objective of this study was to evaluate the post-implantation computed tomography (CT) image quality of different stent types used to treat aortic coarctation.
Adult and paediatric patients with stent-treated aortic coarctation who underwent contrast-enhanced CT were retrospectively included from three tertiary care centres. CT scans were subjectively scored for image quality using a 4-point scale (1 = unacceptable; 2 = poor; 3 = good; 4 = excellent). Furthermore, the amount of stent-induced blooming artefacts was measured as the percentage of the difference between outer and inner stent diameters over the outer stent diameter.
A total of 35 children and 34 adults implanted with 71 stents of six different types were included. The most commonly used stent type was the Cheatham Platinum stent (52 stents, 73%). The subjective image quality of the Cheatham Platinum stents was moderate with a score of 2.0±0.8 (mean ± standard deviation) in children and 2.3±0.6 in adults. The image quality in patients with Formula stents was 2.3±1.2. The Cheatham Platinum stents induced 34–48% blooming, the Formula stents 44–55%. The image quality in patients with the less commonly used Atrium Advanta V12, IntraStent, AndraStent and Palmaz stents was scored 3 (good) to 4 (excellent) with less blooming. The electrocardiographic gating and tube voltage (kVp) did not affect image quality.
There is a substantial variation in CT image quality and blooming artefacts for different stent types used to treat aortic coarctation.
Stent implant is the preferred treatment for aortic coarctation
Contrast-enhanced CT is the modality of choice for follow-up and complications evaluation
Different stent types demonstrated different image quality
Electrocardiographic gating and tube voltage (kVp) did not affect image quality
Aortic stents are commonly used to treat aortic coarctation in both children and adults . Contrast-enhanced computed tomography (CT) is often performed shortly after implantation to assess if complications have occurred during placement (e.g. dissection) and to evaluate the stent position. CT can also be used during follow-up to detect long-term complications such as in-stent stenosis, intimal hyperplasia, stent displacement and aneurysm formation . According to European guidelines , imaging of the aorta should be performed after intervention to document post-implantation anatomy and detect possible complications, with the ideal imaging interval for follow-up depending on the exact baseline pathology. American guidelines  recommend follow-up with CT or magnetic resonance imaging (MRI) at intervals of five years or less after stent placement. Although both MRI and CT can be used , CT is often the modality of choice since in-stent assessment with MRI can be hampered by artefacts .
Several stent types are commercially available and used . Stents were traditionally made of stainless steel, but nowadays different stent materials like cobalt-chromium and platinum-iridium alloys are used as well. It is known that the stent material has a large influence on image quality and stent lumen assessment with CT in coronary stents . However, studies investigating the effect of different stent types on CT image quality for coarctation stents are lacking. Therefore, in this multicentre study the image quality as well as the presence and extent of blooming artefacts generated by different types of aortic stents on CT images were evaluated in patients treated for aortic coarctation.
This study was performed at three tertiary centres in two different countries. At each centre, the study was approved by the local institutional review boards (protocol numbers 16/243/C, MEC-2016-281 and 290REG2016, respectively). A waiver for the requirement for informed consent was granted at all institutions because the study only involved analysis of previously acquired data.
Patients with aortic coarctation who underwent a catheterisation procedure between 2003 and 2016 were included using the local catheterisation registries. Patients in whom an aortic stent was placed as well as patients who underwent re-dilatation of a previously implanted aortic stent were selected. Subsequently, a picture archiving and communication system (PACS) was searched to select patients who underwent contrast-enhanced CT angiography after implantation. In case multiple follow-up scans were available for a patient, only the first scan after implantation was analysed. Exclusion criteria were an unknown stent type and multiple overlapping stents. For each patient, sex, date of stent implantation, weight and height at implantation and stent type were recorded. Coded data were used for analysis.
A study flowchart is provided in Fig. 1. In total 96 patients were eligible in three different centres. Eleven patients were excluded because the stent type was unknown, and 16 patients were excluded because multiple overlapping stents were present. Therefore, 69 patients were included of whom 35 were 18 years or younger at the time of stent implantation (paediatric patients).
For all acquisitions, the following parameters were recorded: date; whether or not electrocardiographic gating or triggering was used; heart rate; tube current in milliamperes (mA); tube peak voltage (kVp); volumetric CT dose index; dose length product; CT system; and reconstruction slice thickness. The CT protocols adopted at each centre are summarised in Table 1. Characteristics of the CT acquisitions in the paediatric and adult populations are displayed in Table 2.
Image quality assessment
The overall subjective image quality of both the aortic lumen and the aortic wall at stent level was scored by one radiologist (SB) with five years of CT experience. The aortic wall was scored at three levels (proximal, central and distal third of the stent). Overall subjective image quality of the aortic lumen at the stent level was scored as (1) unacceptable, non-diagnostic image quality; (2) poor, limited diagnostic value; (3) good, diagnostic image quality; or (4) excellent, optimal diagnostic image quality. Subjective image quality of the aortic wall at stent level was assessed as (1) unacceptable, non-diagnostic image quality of the aortic wall, aortic wall not assessable due to severe artefacts or excessive noise; (2) poor, image quality of the aortic wall with limited diagnostic value, aortic wall is assessable but partially obscured due to moderate artefacts or noise; (3) good, diagnostic image quality of the aortic wall, possible to diagnose/exclude aortic wall abnormalities with minor artefacts or noise; or (4) excellent, excellent image quality of the aortic wall, possible to diagnose/exclude aortic wall abnormalities without artefacts or noise. Furthermore, it was evaluated if the stent was adjacent to the aortic wall. If there was a distance of ≥ 5 mm between the proximal and/or distal part of the stent and the aortic wall, the stent was judged as not adjacent.
A random sample of one third of the cases (n = 23) was scored twice by the same observer with an interval of at least two months in between to assess intra-observer variability. The observer was blinded to the previous scores. The same sample was scored by a second observer (RB), a radiologist with ten years of experience in cardiovascular imaging, to assess inter-observer variability. The second observer was blinded to the results of the first observer.
Objective image quality was evaluated by one observer with three years of CT experience (AH) using a bone setting (window width 1600, window level 300). A region of interest (ROI) was placed in the aorta at the level of the pulmonary trunk using thin slice reconstructions with a dedicated angiographic kernel. The ROI was drawn as large as possible without including the vessel wall. In the same slice an ROI was placed in the muscle tissue. Noise was defined as the standard deviation (SD) in Hounsfield units (HU) of the ROI. The signal-to-noise ratio was defined as the ratio between the mean HU and the SD of the same ROI. The contrast-to-noise ratio was calculated using the following equation [8,9,10]:
The area-derived stent diameter was measured at three levels at the proximal, central and distal thirds of the stent using a bone setting (window width 1600, window level 300). Multiplanar reformations were used to obtain a cross-sectional plane of the stent where the measurements were taken. Both the inner and the outer stent diameters were derived. Stent struts can appear thicker than they are in reality due to metal-related artefacts such as blooming, scatter and partial volume averaging, which may lead to the spurious appearance of obstruction of the stent lumen on CT images. For simplification we will refer to this type of artefact as blooming, which was calculated by the following formula :
Furthermore, the influence of stent diameter on image quality was assessed. For this purpose, the mean of the outer and inner diameters was used, averaged over three measurements (proximal, central, distal). We assessed if the subjective image quality and the aortic wall image quality were significantly different between electrocardiogram (ECG)-gated and non-ECG-gated acquisitions and if the image quality differed for different tube voltage or current (mA) levels.
Objective image analysis was performed using PACS viewers. Subjective image analysis and diameter measurements were performed locally using the PACS at one institution and centrally with the same multimodality workstation with multiplanar reconstructions for the other two centres.
Assessment of complications
Each scan was assessed regarding the presence of any anomalies/complications in regard to the stent structure and position, the aortic wall and aortic branches. The official reports were also retrospectively evaluated. Thereafter, patients’ files were retrieved to assess if the changes were already mentioned in the description of the procedure and if the patient underwent further examination that confirmed the CT findings. Furthermore, medical records were checked to verify if any change in patient management directly related to the CT findings had been undertaken.
SPSS version 21.0 for Windows (IBM, Armonk, NY, USA) and RStudio version 1.0.153 (RStudio, Inc., Boston, MA, USA) were used for statistical analysis. Values are displayed as mean ± SD unless stated otherwise. Differences in scores between stent types were assessed with the Mann-Whitney U test. The influence of ECG gating, kilovoltage and milliamperes on image quality was tested using the χ2 test, Fisher’s exact test and the Kruskal-Wallis test. The correlation between blooming artefacts and kilovoltage and milliamperes was investigated with the Spearman correlation coefficient. A p value below 0.05 was considered statistically significant. To assess the intra-observer agreement and reliability, the percentage of agreement and the quadratic weighted κ were calculated. For the remaining data, descriptive analysis was used.
Baseline patient characteristics are provided in Table 3. All adults had the Cheatham Platinum stent (NuMed Inc., Hopkinton, NY, USA) implanted, while different stent types were used in the paediatric patients, namely Cheatham Platinum (n = 18), Atrium Advanta V12 (n = 5, Atrium, Maquet Holding B.V. & Co. KG, Rastatt, Germany), IntraStent (n = 4, EV3 Inc., Plymouth, MN, USA), Formula (n = 3, Cook Medical, Bloomington, IN, USA), AndraStent (n = 4, Andramed GmbH, Reutlingen, Germany) and Palmaz (n = 3, Johnson & Johnson, New Brunswick, NJ, USA). The characteristics of the different stents are provided in Table 4. An example of CT images of the different stents is provided in Fig. 2. Two paediatric patients had two stents which were not overlapping. The mean stent diameter was 15±4 mm.
ECG gating was used in 54% of paediatric and 59% of adult patients. The heart rate was higher in paediatric patients: 82±28 beats per minute (bpm) compared to 73±21 bpm in adults. The tube current and tube peak voltage were lower in the paediatric population, resulting in a lower radiation dose. The majority of acquisitions (83% paediatrics, 85% adults) were performed on ≥ 64 slice scanners.
Subjective and objective image quality results are provided in Table 5. Objective image quality was comparable between paediatrics and adults. The Cheatham Platinum and Formula stents had an overall subjective image quality of the lumen between 2 (poor) and 3 (good). Formula stents also had a relatively small stent diameter of 6±1 mm. Other stents scored good (score 3) to excellent (score 4), namely 3.4 (Atrium Advanta V12), 3.5 (IntraStent), 3.8 (AndraStent) and 4.0 (Palmaz). The results for the aortic wall image quality were similar, with poor scores for the Cheatham Platinum stent while the other stents scored good to excellent. When comparing Cheatham Platinum stents against each of the other stent types, the differences in subjective scores were statistically significant at all levels and for all stents (Advanta Atrium V12: lumen p = 0.003, proximal aortic wall p = 0.001, central aortic wall p < 0.001, distal aortic wall p = 0.050; Formula: proximal aortic wall p = 0.006, central aortic wall p = 0.002, distal aortic wall p = 0.019; IntraStent: lumen p = 0.001, proximal aortic wall p < 0.001, central aortic wall p < 0.001, distal aortic wall p < 0.001; Palmaz: lumen p < 0.001, proximal aortic wall p < 0.001, central aortic wall p < 0.001, distal aortic wall p = 0.001; AndraStent: lumen p < 0.001, proximal aortic wall p = 0.001, central aortic wall p < 0.001, distal aortic wall p = 0.003) with the exception of the image quality score of the lumen for the Formula stent (p = 0.564). An example of the different scores for the aortic wall image quality is provided in Fig. 3. In Fig. 4 a case example of a patient with both a Cheatham Platinum stent and an AndraStent illustrates the differences in image quality between the stents. Seventeen percent (12/71) of the stents were not completely adjacent to the aortic wall.
The subjective image quality and the aortic wall image quality were not significantly different between ECG-gated and non-ECG-gated acquisitions. Also the tube voltage and current did not significantly alter the subjective image quality of the overall lumen (p = 0.703 and p = 0.425, respectively) or of the aortic wall at the proximal (p = 0.412 and p = 0.263, respectively) and distal thirds (p = 0.568 and p = 0.225, respectively). A weak influence on the image quality of the aortic wall at the level of the central third of the stent was found for the tube peak voltage (p = 0.038) but not for the tube current (p = 0.227).
The percentages of blooming per stent type are provided in Table 6. Blooming was highest for the Formula stent (55% at the centre of the stent). Also the Cheatham Platinum stents were associated with considerable blooming, namely 48% in paediatrics and 42% in adults. In the remaining stents, there was 22–37% blooming. In most stent types, blooming was higher at the centre of the stent compared to the outlets. A weak negative correlation was found between milliamperes and blooming artefacts at all levels of the stents (proximal, ρ = −0.345, p = 0.003; central, ρ = −0.299, p = 0.012; distal, ρ = −0.258, p = 0.031). No influence of tube peak voltage on blooming artefacts was found (proximal, p = 0.085; central, p = 0.285; distal, p = 0.122).
The influence of the stent diameter on the image quality was only assessed for the Cheatham Platinum stents, since only a limited number of stents were included for the other stent types. The results are provided in Table 7. A bigger stent diameter was associated with a higher subjective image quality and image quality of the aortic wall as well as less blooming.
Intra- and inter-observer reliability and agreement
Intra-observer agreement for subjective image quality was 96%. Agreement for the image quality of the aortic wall at stent level was 96%, 87% and 79% for the proximal, central and distal parts of the stent, respectively. The intra-observer reliability was excellent with a weighted κ of 0.955 for the overall subjective image quality and 0.973, 0.928 and 0.848 for the image quality of the aortic wall for the proximal, central, and distal parts of the stent, respectively.
Inter-observer agreement for the subjective image quality of the lumen was 67%. Agreement for the image quality of the aortic wall at the proximal, central and distal parts of the stent was 63%, 63% and 42%, respectively. The inter-observer reliability was good with a weighted κ of 0.695 for the overall subjective image quality and 0.755 and 0.763 for the image quality of the aortic wall for the proximal and central parts of the stent, respectively. The inter-observer reliability for the image quality of the aortic wall at the level of the distal part of the stent was moderate with a weighted κ of 0.529. In no cases was the difference between the scores of the two observers more than one point.
Detection of anomalies/complications
In total, 1 active bleeding, 1 pseudoaneurysm, 11 branches arising from the stent, 1 occluded branch, 2 cases of suspected intimal hyperplasia, 8 cases with focal stricture of the stent and 2 cases with both a stricture and a branch emerging from the stent were found.
In two cases the presence of a portion of the stent with a smaller diameter noticed on the CT scan had not been previously mentioned in the report of the stent implantation procedure. In one of these cases, as a consequence of the CT finding, the patient underwent an angiographic procedure that confirmed the restenosis, as well as its haemodynamic significance, and allowed subsequent re-dilatation. The procedural reports of the cases in which the active bleeding and the pseudoaneurysm were found on the follow-up CT scans indicated a regular and uneventful intervention. Following the CT scan, the first patient with a massive haemorrhage was operated upon but died the same day. For the second patient a conservative management was undertaken after the CT scan, and a later exam showed complete reabsorption of the pseudoaneurysm. The two cases with suspicion of intimal hyperplasia were not further investigated. In the other cases, the CT findings did not result in a modification of the patient management.
Coarctation of the aorta represents 5–10% of the cases of congenital heart disease . In former times the only treatment option was surgery; however, since the 1980s transcatheter treatment with balloon angioplasty and, since the 1990s, stent implantation have evolved . Data from the American College of Cardiology’s National Cardiovascular Data Registry of 671 transcatheter procedures in patients with aortic coarctation show that balloon angioplasty is the most common treatment (50.5%), followed by stent treatment (37.9%) or a combination of both (11.6%) . Until March 2016, there were no US Food and Drug Administration (FDA)-approved stents for use in the aorta; therefore, stents were used off-label for this indication . In 2016 the Cheatham Platinum stent obtained FDA approval, while the stent already had a CE mark for use on the European market . A prospective multicentre trial involving 105 patients showed that the Cheatham Platinum stent is safe and effective . Data on the safety and effectiveness of off-label stents are absent or limited to small retrospective studies [11, 15,16,17]. The choice to implant a specific type of stent relies on clinical and anatomical characteristics of the patients such as age, diameter of the aorta and of the stricture, previous operations/interventions, site of the lesion and anatomy of adjacent aorta and aortic branches .
There is consensus that follow-up imaging should be performed after stent implantation; however, the modality and the time interval are less clear [3, 4]. Early on, follow-up is necessary to rule out aortic rupture and delayed bleeding. Later on, other complications like delayed aneurysm formation, restenosis or fracture of the stent might occur. A consortium study with data from 34 centres and 302 patients showed that CT is the most often used imaging modality for follow-up . Three months after implantation, 63% of patients had undergone a follow-up CT, while cardiac catheterisation (10%) and MRI (12%) were less commonly used. In 16% of patients no follow-up imaging was performed .
Although CT is commonly used for follow-up of stents implanted for aortic coarctation, data on the image quality of different stent types on CT are lacking. In this multicentre evaluation of the CT image quality in patients with aortic coarctation implanted with aortic stents, we showed that the most commonly used stent type (Cheatham Platinum) is associated with moderate but still diagnostic image quality on CT, while less commonly used stent types were associated with superior image quality. In addition, ECG gating and tube voltage did not demonstrate any effect on image quality.
The Cheatham Platinum stent consists of a platinum-iridium alloy and joints over brazed with gold. The other stent types are made of 316 L stainless steel (Atrium Advanta V12 and Formula), stainless steel (IntraStent and Palmaz) and a cobalt-chromium alloy (AndraStent). Our results regarding the Cheatham Platinum, i.e. the association with a worse but still diagnostic image quality, are in agreement with the in vitro study by Köhler et al. , who evaluated 22 different types of peripheral artery stents with CT angiography. A poorer image quality was reported for the platinum-iridium and tantalum stents due to blooming artefacts. They attributed this to the higher atomic number of platinum (78) and tantalum (73) compared to cobalt (27), steel (26) and chromium (24) . Other factors which might have an effect on image quality besides the stent material are the stent diameter, strut design and acquisition parameters. In the current study we assessed the influence of stent diameter on the image quality for the Cheatham Platinum stent, and smaller stent diameters were associated with poorer image quality and a larger amount of blooming. This might also explain the results of the Formula stent, which was associated with moderate diagnostic image quality and substantial blooming. However, patients receiving the Formula stent were on average three years old; therefore, the smaller stent diameters used in those young children might explain the moderate image quality. The subjective image quality of Cheatham Platinum stents with a diameter below 15 mm was poor; however, the number of patients in this subgroup analysis was small. Although the image quality of Cheatham Platinum was poor for stents with a small diameter, CT might still be the preferred imaging modality for follow-up in small children because it is relatively non-invasive and adjacent organs can be assessed as well. Although the number of patients with different stent types was too small for analysis, the objective image quality of the scan did not seem to have an impact on the subjective image quality of the stent.
We found a weak negative correlation between tube current and percentage of blooming. Conversely, no effect of ECG gating and tube voltage on image quality was demonstrated, with the exception of a weak association between tube voltage and image quality of the aortic wall at the middle third of the stent. This might seem to contradict previous studies which reported a reduction in terms of metal artefacts by employing reconstructions with higher energy levels obtained from dual energy scans [20,21,22]. However, in our study the limited number of scans per kVp category and, especially, the additional differences in other scanning parameters are likely to have influenced the results. Moreover, our subjective scoring system was focussed on the diagnostic value of the image quality, which does not exactly correspond to the amount of artefacts . Therefore, further studies with more standardised imaging protocols are necessary to establish if dual-energy scans and monochromatic reconstructions can improve the image quality of aortic stents.
This is the first large patient study that systematically compares the CT image quality of different stent types used for the treatment of aortic coarctation. It provides insights into differences between stent types and the associated amount of blooming. However, this study has limitations. First, the retrospective design implied that different CT systems and different protocols were used. As a consequence, it was not possible to study the influence of parameters like contrast medium, kernel and reconstruction technique due to the large heterogeneity of the collected data. However, this resembles the real-world situation in which differences between hospitals are common. Second, the number of patients receiving a stent other than the Cheatham Platinum was limited. Therefore, we could only assess the influence of the stent diameter for the Cheatham Platinum stents, since data for the other stent types were insufficient due to small numbers. Third, the true diameter to which the stent was inflated during angiography was often unknown. Therefore, it was not possible to investigate if the stent diameter measured on CT images differed from the true stent diameter. Finally, although the subjective score for image quality was designed to assess if the image quality was diagnostic, in this study we did not investigate the CT diagnostic accuracy in the absence of a reference test such as angiography performed at the same time. However, the occlusion of aortic branches and their origin from the stent as well as the presence of strictures of the stent frame were detected on CT images. Furthermore, the two most relevant complications occurring in this study population (active bleeding and pseudoaneurysm) were identified on CT examinations.
In conclusion, this study provides insights into the image quality and blooming artefacts of different stent types used to treat coarctation of the aorta on CT images. Both radiologists and clinicians should be aware of these differences when prescribing imaging exams, writing reports and interpreting the results. Radiologists should provide detailed information of the image quality of the CT scans in addition to the findings.
Magnetic resonance imaging
Picture archiving and communication system
Region of interest
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Boccalini, S., den Harder, A.M., Witsenburg, M. et al. Computed tomography image quality of aortic stents in patients with aortic coarctation: a multicentre evaluation. Eur Radiol Exp 2, 17 (2018). https://doi.org/10.1186/s41747-018-0046-5
- Aortic coarctation
- Tomography, x-ray computed
- Image quality