Magnetic resonance imaging (MRI) is an important part of breast cancer diagnosis and multimodal workup. It provides unsurpassed soft tissue contrast to analyse the underlying pathophysiology, and it is adopted for a variety of clinical indications. Predictive and prognostic breast MRI (P2-bMRI) is an emerging application next to these indications. The general objective of P2-bMRI is to provide predictive and/or prognostic biomarkers in order to support personalisation of breast cancer treatment. We believe P2-bMRI has a great clinical potential, thanks to the in vivo examination of the whole tumour and of the surrounding tissue, establishing a link between pathophysiology and response to therapy (prediction) as well as patient outcome (prognostication). The tools used for P2-bMRI cover a wide spectrum: standard and advanced multiparametric pulse sequences; structured reporting criteria (for instance BI-RADS descriptors); artificial intelligence methods, including machine learning (with emphasis on radiomics data analysis); and deep learning that have shown compelling potential for this purpose. P2-bMRI reuses the imaging data of examinations performed in the current practice. Accordingly, P2-bMRI could optimise clinical workflow, enabling cost savings and ultimately improving personalisation of treatment. This review introduces the concept of P2-bMRI, focusing on the clinical application of P2-bMRI by using semantic criteria.
Magnetic resonance imaging (MRI) is an essential imaging modality for the assessment of breast diseases; it investigates the entire tumour volume in vivo as well as the surrounding tissue and the whole breast(s) providing imaging biomarkers for both prediction and prognostication.
Predictive breast MRI may establish the link between imaging information and therapeutic decision-making.
Prognostic breast MRI may enable us to foresee the patient outcome.
Predictive and prognostic breast MRI (P2-bMRI) reuses already performed MRI examinations and does not require additional invasive tissue sampling or potentially expensive analytic procedures.
P2-bMRI promises great benefits to clinical workflow, allowing cost savings and personalisation of treatment.
Magnetic resonance imaging (MRI) represents an important part of multimodal breast imaging [1,2,3,4,5,6]. Based on three-dimensional multiparametric imaging, it provides high soft tissue contrast enabling functional insights into the pathophysiology of breast disease [2, 6]. Such qualities translate into its unsurpassed sensitivity and negative predictive value [7, 8].
Multiple indications to perform MRI in clinical practice are established and may be summarised by few key questions of breast imaging: “Is there a lesion?” (detection in both screening and diagnostic scenarios); “Is the lesion malignant?” (characterisation and problem-solving), “Where is the lesion located? Are there are other suspicious ipsilateral or contralateral lesions? How much is the disease extended in relation with the breast volume?” (preoperative locoregional staging), and “Is the tumour responding to neoadjuvant therapy?” (treatment monitoring) [3, 4, 9,10,11]. These clinical indications are mostly accepted worldwide. The only exception concerns the role of breast MRI in preoperative locoregional staging. The final results of a large multinational investigation (the MIPA study) recently provided important real-world data on this matter [10, 12], but this indication remains a matter for debate.
Predictive and prognostic breast MRI (P2-bMRI) is an emerging application next to these indications. Generally, P2-bMRI may be approached as an umbrella term summarising tools aimed at one general objective. Such general objective of P2-bMRI is to provide predictive and/or prognostic MRI biomarkers. Such imaging biomarkers may ultimately support the personalisation of breast cancer treatment . P2-bMRI applies a wide spectrum of tools to achieve this general objective: standard and advanced multiparametric pulse sequences, structured reporting criteria (for instance BI-RADS descriptors), artificial intelligence methods, including machine learning (with emphasis on radiomics data analysis), and deep learning that have shown compelling potential for this purpose [14,15,16,17,18,19].
P2-bMRI is different to traditional biomarkers; it does typically not require additional patient examinations but recycles imaging data already available from routine breast MRI [20, 21]. Accordingly, P2-bMRI may transform breast MRI into a one-stop shop examination, hence providing both diagnostic and predictive/prognostic information. Already now, MRI is routinely performed in many state-of-the-art breast imaging units, for example for preoperative staging. In this case, data required for P2-bMRI are already available in an great number of patients [3, 9]. Whereas alternative biomarkers typically rely on invasive tissue sampling and may require potentially expensive analytical procedures, this is not the case for P2-bMRI [20,21,22]. Thus, P2-bMRI holds great promises related to patient workflow, treatment personalisation, and cost-effectiveness of breast cancer treatment.
This narrative review introduces the concept of P2-bMRI and presents its potential advantages. Tools available for P2-MRI are discussed. Hereby, special focus is set on the clinical application of P2-bMRI by using semantic criteria.
The role of P2-bMRI in the perspective of P4 medicine
Personalised, predictive, preventive, and participatory (P4) medicine is a key concept for state-of-the-art oncology . In breast cancer care, P4 medicine aims to tailor therapy to the individual patient and the specific tumour biology. In order to translate P4 medicine into clinical practice, new diagnostic methods and refinement of existing tools are required [23, 24].
P2-bMRI can be used to provide imaging biomarker supporting personalisation of breast cancer diagnosis and treatment, i.e., screening strategies based on patient-based data and therapies based on specific tumour- and patient-based data. Therefore, P2-bMRI may become an important driver for the translation of P4 medicine into clinical practice. In the following, we summarise the concept of precision medicine and discuss how P2-bMRI will help to bridge critical research gaps in this field .
Precision medicine aims to adopt therapy based on specific characteristics of the individual patient, including disease susceptibility, biology, and prognosis as well as response to treatment [13, 24,25,26]. Molecular subtyping is a classic example how specific biological characteristics of breast cancer aid personalisation of patient treatment in current clinical practice . Hereby, molecular subtyping provides decision support on whether and what systemic therapy should be appropriate, such as endocrine therapy in luminal cancers, targeted therapy in human epidermal growth factor receptor 2 (HER2)-positive cancers, or immune therapy in triple negative cancers [13, 27]. Precision medicine may be further improved by genetic microarrays. It has been demonstrated that genetic microarrays can distinguish patients who ultimately benefit from cytotoxic treatment from those women where chemotherapy may safely be omitted [20, 28]. Regardless of these advances, personalisation of therapy is still at a relatively early stage of development, judged to be a critical research topic . Although steps forward in this direction were done in the last decades, the contribution of noninvasive techniques such as MRI is a highly interesting option to be considered [29,30,31].
Prognostic and predictive biomarkers and their relevance for precision medicine
Biomarkers are critical elements for the development of precision medicine [24, 32]. Eccles et al.  called for the development of “imaging biomarkers” in a systematic gap analysis on most urgent breast cancer research topics. Authors expect that “validation of multimodality imaging biomarkers” will provide a better understanding of biological breast cancer behaviours, hereby supporting the personalisation of treatment .
Per definition, any specific “characteristic that is measured as an indicator of normal biological processes, pathogenic processes, or responses to an exposure or intervention, including therapeutic interventions” may be regarded as a potential biomarker [32, 33]. Two types of biomarkers are of special interest for the concept of precision medicine: prognostic and predictive biomarkers. The former provides information about overall disease outcome. They may be used to identify patients who actually may benefit from certain types of treatments. Whereas prognostic biomarkers do not provide information about which individuals are likely to benefit from a specific therapy, this may be achieved by predictive biomarkers. Accordingly, predictive biomarkers may support clinicians in selecting the most appropriate type of treatment for the individual patient [34,35,36]. While this differentiation (prognostic versus predictive biomarkers) is relevant, we should consider that there is an obvious interplay between prognostication and prediction. With reference to the P4 medicine , we should consider that the second P (“predictive”) includes both prognostication outcome prediction.
Biomarkers from breast MRI
Application of P2-bMRI as a source of prognostic and predictive biomarkers can aid personalisation of treatment. This ultimately may bridge critical research gaps in the successful treatment of breast cancer . In comparison with traditional biomarkers, such as histopathological (type/grading) and molecular and genetic examinations (receptor status, multigene arrays), MRI biomarkers offer specific advantages due to the intrinsic characteristics of the method, as specified below.
P2-bMRI investigates the whole tumour in vivo. P2-bMRI hereby potentially reducing the risk of sampling errors [37, 38]. Moreover, also, the surrounding tissue (e.g., background parenchymal enhancement [BPE] and peritumoural environment, especially oedema, as described below) and the whole breast(s) can be potentially considered. In contrast, conventional biomarkers may rely on samples taken from specific selected tumour regions.
P2-bMRI does not require invasive tissue sampling and allows to visualise the tumour in vivo. It is commonly well-tolerated by patients and has no absolute contraindications except those related to the presence of unsafe ferromagnetic implanted and/or electronic medical devices.
P2-bMRI may transform breast MRI in a one-stop shop solution providing both diagnostic and predictive/prognostic information. While the indication for preoperative MRI is still the subject of debate, it is already regularly performed in clinical practice [9, 10, 12]. In these patients, the data required for P2-bMRI are readily available, and costly additional investigations are not required. Accordingly, P2-bMRI promises significant cost savings for treatment personalisation. In contrast, alternative tumour profiling methods are known cost drivers, so limiting their broader application as recently argued to Bhargava et al. .
P2-bMRI provides intrinsic advantages to the clinical workflow as all data could be available in real time.
Predictive/prognostic data from P2-bMRI can be complementary to conventional biomarkers. So, P2-bMRI may fine tune the prognostic assessment of patients, which have been initially assessed by conventional biomarkers .
Triaging patients by P2-bMRI
Application as a gatekeeper is a promising use case of P2-bMRI. Here, the method will serve as a triage tool to select patients for more advanced procedures of precision medicine such as genetic testing [22, 38]. Triaging breast cancer patients for genetic testing have been advocated by Bhargava et al. . Authors argue that genetic tests are costly, not generally available, and changes in treatment affect only a subgroup of patients . They have developed triage tools to safely forego molecular testing based on standard histological examinations . Validation studies demonstrated that triaging can obviate molecular testing in the majority of patients without compromising oncologic safety. At the same time, cost savings of US $3,000 are achieved for every skipped molecular test . Accordingly, Bhargava et al.  expect an enormous healthcare value of triage tools in the era of precision and P4-medicine.
The correlation of MRI data with molecular profiling and genetic tests has been independently verified by many authors [40,41,42]. Hence, P2-bMRI may be adopted as a triage tool similar to the concept of Bhargava et al. . As previously described, P2-bMRI provides results in real time without the need of additional invasive and analytic procedures. Therefore, we expect a potential of P2-bMRI as a triage tool in precision medicine, such as a valuable help for selecting patients for genetic testing.
Technical requirements for P2-bMRI
Technical requirements for an up-to-date P2-bMRI are the same as for any diagnostic breast MRI [2, 4]. An overview is given in Fig. 1. In short, a state-of-the-art full protocol breast MRI protocol should include a T2-weighted sequence, a diffusion-weighted sequence, and a dynamic T1-weighted sequence (i.e., before/after intravenous application of a gadolinium-based contrast agent) [52, 53]. Particular attention should be given to the quality of diffusion-weighted images, possibly taking into consideration the recommendations provided by the European Society of Breast Imaging . Specialised sequences such as spectroscopy and fast sequences for pharmacokinetic analysis are promising to improve future performance of P2-bMRI [65,66,67,68] but are not performed outside specific research projects.
Data analysis of P2-bMRI
Just like in diagnostic MRI itself, the spectrum of tools available for P2-bMRI is broad as well; it ranges from semantic criteria to advanced post-processing techniques, such as artificial intelligence, including radiomics data analysis [14,15,16,17,18,19]. Generally artificial intelligence may address a wide range of clinical use cases including predictive/prognostic tasks [14, 15]. The status of radiomics and artificial intelligence in breast imaging extends beyond the aim of this article and has been reviewed previously [14, 15, 19, 69]. There is no doubt that these methods offer a great advantage for P2-bMRI [14, 15, 17,18,19]. At the current stage, however, these methods are reserved for academic institutions and are not yet suitable for widespread clinical use. Published data are still insufficiently validated independently and externally, which is why the generalisability has not yet been proven .
P2-bMRI: semantic criteria
In contrast, semantic criteria are an integral part of routine breast MRI diagnostics . This enables us to apply P2-bMRI in a large number of patients already today. In the following, we give an overview of how to apply semantic P2-bMRI criteria to clinical breast MRI protocols. Figures 1, 2, 3, 4, 5, 6, and 7 and Table 1 summarise key concepts of this approach.
Background parenchymal enhancement
The vascularisation of normal breast parenchyma is assessed by BPE . In high-risk women, BPE has been identified as a prognostic imaging biomarker of breast cancer risk; women showing at least “mild” BPE are associated with significantly greater odds of future breast cancer (odds ratio: 2.1), which may be explained by deficient tissue repair mechanisms in this subgroup of women [46, 47] (Table 1). However, among average-risk women, the level of BPE is not associated with a higher risk of breast cancer .
The association of current BPE with breast cancer prognostic factors, such as higher mammographic density, steroid receptor status, and lymphovascular invasion has been reported in the literature . Lim et al.  (hazard ratio 3.1) and Choi et al.  (postmenopausal; hazard ratio 3.9) independently reported the association of BPE with recurrence-free survival in average-risk patients with [70, 71]. These data emphasise the future potential of BPE as a genuine MRI imaging biomarker in the personalisation of breast cancer care.
Tumour enhancement: morphology and dynamics
A broad spectrum of semantic criteria is available to characterise breast tumour vascularisation. They may be applied to P2-bMRI as well [43, 50, 63, 72]. Neovascularisation is considered a key step in the process of carcinogenesis . Patterns of neovascularisation can be assessed by microvessel density at traditional pathology examination, and this parameter is regarded a prognostic biomarker of breast cancer by itself . Contrast enhancement is the basis for MRI diagnosis of breast cancer and is thought to reflect tissue vascularisation (Fig. 3) [2, 43]. Accordingly, many authors hypothesised that MRI enhancement patterns correlate with patient outcome and eventually may be used as imaging biomarkers [38, 40, 75].
Wash out is a key diagnostic criterion of the delayed enhancement phase but should also be approached as a prognostic biomarker [2, 43, 63]. It has been identified as a powerful tool to rule out the risk of metachronous metastasis (sensitivity and negative predictive value 100%; criterion, washout rate > 40%) . Although these findings have to be validated in clinical trials, results highlight the potential of P2-bMRI parameters to estimate individual patient risk profile (Fig. 3, Table 1).
Breast cancer is a heterogeneous disease . Volumetric analysis of MRI enhancement parameters investigate the composition of the entire tumour vasculature and are considered an imaging correlate of breast cancer heterogeneity [38, 76] (Fig. 3). Accordingly, the association of volumetric MRI parameters with histopathology and prognostic factors of breast cancer such as lymph node, hormonal receptor, and HER2 status has been demonstrated . Building upon these results, correlation of volumetric MRI enhancement patterns with surrogate-free measure of patient outcome has been demonstrated in the meantime [38, 76]. For example, P2-bMRI has been shown to predict overall survival of breast cancer patients . In a subsequent study, authors demonstrated that volumetric analysis of MRI enhancement yielded synergistic effects to conventional biomarkers . Findings support the hypothesis that P2-bMRI can be used as add-on tool to further refine risk stratification of established prognostic biomarkers.
Rim enhancement is a classic diagnostic pattern of breast MRI [2, 43] (Fig. 6). Its prognostic value was early reported in the literature. Jinguiji et al.  investigated the relationship of this semantic MRI criterion with prognostic factors. Authors reported the significant association of rim enhancement with multiple prognostic factors such as lymph node metastasis, blood vessel invasion, steroid receptors, tumour size, and histological grade (G3 versus G1 or G2: diagnostic odds ratio 6.1; specificity 57.5%) (Table 1) . Rim enhancement is thought to reflect central hypovascularity due to the presence of connective tissue, fibrosis, and/or necrosis in rapidly growing aggressive cancers [60, 61]. On the other hand, the necrosis sign is considered to indicate colliquative (fluid) necrosis, a pattern characterised by high signal intensity inside the cancer on T2-weighted scans . As outlined in Table 1, necrosis sign has been described as one of the most specific semantic MRI criteria of high grade cancers (G3 versus G1 or G2 cancers: diagnostic odds ratio 3.7; specificity 94.3% (Table 1) .
Biomarkers from unenhanced breast MRI
T2-weighted signal intensity of a breast cancer is classified as hyper-, iso-, or hypointense compared to the surrounding breast tissue (Fig. 5, Table 1). In P2-bMRI, this semantic criterion serves as a predictor of tumour proliferation. Biologically less active desmoplastic tumours typically exhibit hypointense signal intensity on T2-weighted scans. In contrast, the presence of a T2-weighted hyperintense cancer suggests increased cellular proliferation and elevated Ki-67 expression (diagnostic odds ratio 2.2, specificity 59.8%) [62, 77].
While rim enhancement and signal intensity on T2-weighted scans investigate the gross anatomy of breast cancer, tumour microstructure can be investigated by diffusion-weighted imaging (DWI). DWI patterns are quantified by the apparent diffusion coefficient (ADC), which is typically used as a quantitative biomarker to aid differential diagnosis of suspicious breast lesions [5, 78, 79]. DWI could be used for P2-bMRI as well, and we regard the assessment of tumour invasiveness by ADC mapping as a promising clinical application . Bickel et al.  reported higher ADC levels for ductal carcinoma in situ (DCIS) compared to invasive cancers. Personalisation of DCIS treatment is based on core biopsy samples, which are known to miss invasive tumour components in a relevant number of patients. Importantly, pure DCIS tumours require a different treatment strategy, which is why delaying correct diagnosis of invasive cancers should be avoided. To solve this dilemma, ADC may be used as a decision support tool . Different to core biopsy, DWI examines the whole tumour, reducing the risk of sampling errors, which leads us to the following use case: if presurgical histology reveals DCIS, but ADC values (as well as patterns of contrast enhancement) are suggestive of invasive cancer, diagnosis of pure DCIS has to be questioned . In this scenario, re-biopsy shall be considered and may avoid delayed diagnosis of invasive cancer as proposed by Bickel et al.  (Fig. 7).
Associated vascular findings
The adjacent vessel sign is a finding related to the macrovasculature of breast lesions. According to Dietzel et al. , the adjacent vessel sign reflects invasiveness of breast cancer. It indicates the presence of invasive cancer and is rarely seen in DCIS (diagnostic odds ratio 2.7, specificity 72.6%)  (Fig. 6, Table 1).
Whole breast vascular maps were investigated by Sardanelli et al. [72, 81] showing the association of an increased unilateral map with the presence of invasive cancers. This association was also shown to allow an increase in specificity using a 3-T magnet . Martincich et al.  studied the variations of vascular maps in the context of primary systemic therapy. They showed that before therapy, vascular maps were asymmetrically increased ipsilaterally to the locally advanced breast cancer. After primary systemic therapy, vascular maps significantly changed only in the breast harbouring the cancer, with responders showing significantly more reduce vascular maps than nonresponders .
Associated nonvascular findings: oedema
The local tumour environment is recognised as a key factor in breast cancer development. It may be studied with semantic MRI criteria . Oedema is defined as an associated finding in the BI-RADS lexicon, and it is characterised by T2-weighted signal increase within the local tumour environment [43, 54] (Fig. 5). It can be classified as perifocal, diffuse, subcutaneous, and prepectoral [39, 54,55,56, 84]. In general, the presence of oedema is indicative of aggressive cancer phenotypes, which is especially true for diffuse and prepectoral patterns [54, 55, 84]. According to Kaiser et al. , the latter is typically associated with lymph node metastases, lymphangitic carcinomatosis, and invasion of the chest wall. Subcutaneous oedema is specific of inflammatory breast cancer . Whereas the majority of studies on the prognostic value of oedema used surrogates of patient outcome [54,55,56, 84], Cheon et al. investigated the impact of perifocal oedema on patient outcome . Authors identified perifocal oedema as an independent biomarker of disease recurrence (hazard ratio 2.48) potentially improving the prognostication of disease recurrence by conventional biomarkers . Meanwhile, the prognostic value of the semantic criterion “oedema” has been verified by numerous authors [86,87,88]. In particular, advanced techniques such as high-resolution diffusion-weighted imaging and radiomics showed promising potential to analyse peritumoural tissue, and they may further support the clinical impact ofP2-bMRI [89,90,91].
Accurate assessment of anatomical tumour extent is the main rationale for preoperative breast MRI locoregional staging [10, 92]. However, this assessment provides significant prognostic information as well; tumour size is a key prognostic factor of breast cancer, and larger tumours are associated with a higher likelihood of worse outcome [92, 93]. Infiltration of breast cancer into associated structures such as the nipple areola complex or into the skin is associated with a poorer patient outcome [92, 94]. Accordingly, Dietzel et al. [52, 53] demonstrated that semantic criteria such as destruction of nipple line (diagnostic odds ratio 2.5, specificity 88.5%) or skin thickening (diagnostic odds ratio 5.9, specificity 94.5%) are associated with a poor prognostic profile such as that defined by the presence of locoregional lymph node metastases (Fig. 6, Table 1).
Occurrence of locoregional and distant metastasis deteriorates prognosis [93, 95]. Whole body MRI is an established tool to detect breast cancer metastasis, and its performance may be further improved by utilising the technology combining positron emission tomography and MRI [96,97,98]. While typical preoperative MRI aims to primarily assess ipsilateral tumour extension and the possibility of contralateral breast cancers, state-of-the-art scanner hardware could actually combine dedicated breast MRI examination with whole-body examinations as suggested by Kirchner et al. . Since significant prognostic information can be derived from whole body MRI examinations, they are promising in the context for P2-bMRI as well [93, 95]. Different strategies exist for whole body examinations in breast cancer care. Kirchner et al.  proposed a complete whole body positron emission tomography/MRI staging. On the other hand, abbreviated protocols enabling screening for breast cancer metastasis are available as well [99, 100]. Requiring only 90 s of additional examination time, such protocols can be combined with a standard breast MRI within one single examination. Initial clinical data demonstrated promising results regarding both lymph node staging (positive predictive value of 100%, negative predictive value of 94.3%) and distant metastases screening (sensitivity 100%, specificity 98.3%) [99, 100].
Breast MRI phenotyping
Highly accurate breast MRI diagnosis is not achieved, until multiple parameters are assessed in concert [1, 2]. The same applies to P2-bMRI. Although individual parameters already enable prognostic assessment (Table 1), the relevance of P2-bMRI can be further specified when the lesion is analysed in the concert of multiple parameters [52, 99]. If these patterns correspond to a specific tumour biology, we refer to this feature combination as P2-bMRI phenotype. Accordingly, P2-bMRI phenotypes can provide actionable information, which is why we expect their key role in translating P2-bMRI into clinical practice.
An example of the use of P2-bMRI for phenotyping using artificial intelligence approach has been proposed by Dietzel et al.  (Fig. 8). Authors aimed to predict axillary lymph node metastases based on semantic MRI parameters of the index cancer. To support clinical application, prediction was based on a minimal number of MRI descriptors, and machine learning methods were used for this purpose [2, 99]. As expected, a single MRI parameter (skin thickening) was already able to predict the risk of axillary lymph node metastases (Fig. 8, Table 1). However, a reliable rule-out criterion (i.e., “no lymph node metastases”) could only be reached when three parameters were combined (Fig. 8, risk of nodal metastasis 0/56 = 0%).
To translate P2-bMRI into P4 breast cancer care, three major challenges should be overcome.
First of all, methodological development of P2-bMRI needs to be refined. It may be achieved at the level of MRI data analysis. Radiomics of individual lesions (and machine learning applied to lesion radiomic data) as well as the use of convolutional neural networks applied to the whole image(s) may be regarded as most promising tools here [15, 19, 69, 102]. Yet, there is still considerable potential for improvement even only based on semantic criteria. Future development of P2-bMRI may also be achieved at the level of data acquisition, and magnetic resonance spectroscopy may be particularly promising here [65, 68].
However, methodological development by itself is not sufficient to translate P2-bMRI into clinical practice. Empiric evidence on P2-bMRI is generally derived from small, monocentric, and retrospective studies. Clinical application will request validation of P2-bMRI in a real-world oncological setting before adopting the methods. This calls for dedicated interdisciplinary, large, multicentre studies, perhaps also randomised controlled trials.
Finally, the breast imaging community itself should try to be a strong promoter in the process of translating P2-bMRI into clinical practice. The prognostic potential of imaging biomarkers is not yet sufficiently recognised outside the field of radiology. Only when radiologists and nuclear medicine physicians dedicated to breast imaging will be successful in convincing key stakeholder such as patients, clinical colleagues, healthcare providers, and MRI vendors, P2-bMRI will start to be an integral part of routine breast cancer care.
Apparent diffusion coefficient
Background parenchymal enhancement
Ductal carcinoma in situ
Human epidermal growth factor receptor 2
Magnetic resonance imaging
Predictive and prognostic breast magnetic resonance imaging
Personalised, predictive, preventive, and participatory
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Work conceptualisation, MD, PATB, and FS; literature search and analysis, MD, PATB, MD, PATB, RMT, and MZ; manuscript writing, MD and PATB; manuscript substantial revision, all authors. The authors read and approved the final manuscript.
Matthias Dietzel and Pascal Baltzer are members of the European Radiology Experimental Editorial Board. They have not taken part in the review or selection process of this article. Francesco Sardanelli is the Editor in Chief of European Radiology Experimental. He has not taken part in the review or selection process of this article which was fully managed by the Deputy Editor Akos Varga-Szemes (Medical University of South Carolina, Charleston, SC, USA). All remaining authors declare that they have no competing interests.
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