Fig. 3

Schematic representation of the 1-tissue compartment model and six derived phantom configurations. A distinction is made between three phantom types: basic, aligned capillaries and tissue filled (black spheres). Moreover, the microvasculature and tissue can be simulated as one combined (a) or two separated volumes (b) (e.g., via a porous membrane). C_p and C_t represent the concentration of the compound of interest (is being imaged) in the simulated blood plasma and tissue, respectively. K₁ and k₂ comprise the two transfer coefficients. Formation of in- and outgoing flow (arrow) and compartment flow varies per individual phantom design