Fig. 1

System representation of ground truth validation process of quantitative perfusion imaging (PI). The diverse input variables that might affect quantitative perfusion outcomes are shown on the right. Q serves as an example input variable and refers to set phantom flow in mL/min. BF is accordingly the computed blood flow in mL/min (system output), and r is the residual between both. The latter can be translated into a measure of accuracy. The figure summarises the central topics of this review paper