Table 3 Baseline magnetic resonance imaging flow, perfusion, and transverse relaxation time (T2*) data for healthy participants and patients with compensated cirrhosis (CC)
Parameter | Healthy subjects (HS) | Compensated cirrhosis (CC) | Baseline HS versus CC p value | ICC | |||
|---|---|---|---|---|---|---|---|
Baseline | CoV (%) | Baseline | CoV (%) | ||||
Portal vein | Area (mm2) | 94.4 ± 25.5 | 7.3 ± 4.4 | 138.5 (92.4–141.7) | 3.8 ± 2.6 | 0.063 | 0.984 |
Velocity (cm/s) | 13.2 ± 2.7 | 9.4 ± 7.6 | 13.7 ± 2.9 | 4.9 (4.2–5.6) | 0.694 | 0.924 | |
Flux (mL/s) | 12.0 ± 3.1 | 6.8 (5.7–11.0) | 16.3 ± 4.5 | 5.7 ± 1.9 | 0.022a | 0.979 | |
Hepatic artery | Area (mm2) | 24.6 ± 4.8 | 5.5 (3.9–7.9) | 20.7 (19.8–23.4) | 5.7 (2.7–8.5) | 0.278 | 0.942 |
Velocity (cm/s) | 18.0 ± 3.5 | 9.4 (7.8–19.4) | 16.2 (11.5–24.2) | 7.9 ± 3.5 | 0.720 | 0.985 | |
Flux (mL/s) | 4.5 ± 1.5 | 15.4 ± 8.5 | 3.5 (2.8–5.0) | 7.5 ± 4.5 | 0.315 | 0.975 | |
Total hepatic blood flow (mL/s) | 16.2 ± 4.1 | 8.4 (5.6–9.5) | 20.9 ± 5.0 | 5.5 ± 3.6 | 0.038a | 0.972 | |
Azygos vein | Area (mm2) | 21.6 ± 6.3 | 6.0 (4.3–7.4) | 20.8 (18.7–33.1) | 2.5 (1.0–3.5) | 0.635 | 0.985 |
Velocity (cm/s) | 10.1 ± 4.9 | 9.3 ± 4.4 | 13.4 ± 3.7 | 7.1 ± 5.0 | 0.144 | 0.977 | |
Flux (mL/s) | 2.0 ± 0.6 | 14.7 ± 9.7 | 2.9 (2.3–5.0) | 8.5 ± 5.2 | 0.042a | 0.994 | |
Liver perfusion (mL/100 g/min) | 212.9 ± 53.9 | 11.2 ± 12.5 | 219.6 ± 75.5 | 12.5 ± 9.1 | 0.826 | 0.773 | |
Arrival time of blood to liver (ms) | 545 (499–604) | 17.1 (4.9–41.3) | 367 ± 89 | 26.1 ± 17.2 | 0.034a | 0.793 | |
T2* (ms) | Mode | 17.8 ± 3.7 | 2.5 ± 1.3 | 14.5 ± 5.3 | 1.4 (1.3–2.7) | 0.126 | 0.996 |
FWHM | 8.8 ± 2.3 | 4.4 (3.8–6.1) | 7.8 ± 2.1 | 13.1 ± 10.1 | 0.294 | 0.930 | |