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European Radiology Experimental
Fig. 1 | European Radiology Experimental

Fig. 1

From: Hyperpolarized [1-13C]-pyruvate MRS evaluates immune potential and predicts response to radiotherapy in cervical cancer

Fig. 1

Study overview. Radiation therapy induces the abscopal effect that triggers metabolic alterations in immune system. Intravenously administration of hyperpolarized (HP) [1-13C]-pyruvate is rapidly distributed to spleen via arterial inflow, entering the interstitial space and being transported into the intracellular space. The pyruvate metabolism in the human spleen can be probed using magnetic resonance spectroscopy non-invasively, by measuring the HP [1-13C]-pyruvate to [1-13C]-lactate conversion via cytosolic lactate dehydrogenase (LDH), [1-13C]-alanine via cytosolic alanine transaminase (ALT), and [.13C]-bicarbonate (HCO3) via mitochondrial pyruvate dehydrogenase (PDH) and carbonic anhydrase (CA)

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