Table 2 Summary of cohort population’s clinical, radiological, and pathological data
Variable | Total cohort | NMI-UTUC (< pT2) | MI-UTUC (≥ pT2) | p-value* |
|---|---|---|---|---|
Clinical features (per patient) | ||||
Sample size, n (%) | 30 (100) | 13 (43.3) | 17 (56.7) | - |
Age, years, median (IQR) | 73 (67–77.5) | 70.0 (67–74) | 74 (67–81) | 0.602 |
Gender, n (%) | ||||
Female | 12 (40.0) | 5 (16.7) | 7 (23.3) | 0.880 |
Male | 18 (60.0) | 8 (26.7) | 10 (33.3) | |
Positive smoking history, n (%) | 20 (66.7) | 9 (30.0) | 11 (36.7) | 0.794 |
Body mass index (kg/m2), median (IQR) | 24.5 (23.0–27.7) | 25.7 (24.8–27.5) | 23.4 (22.2–27.7) | 0.127 |
Presence of hematuria, n (%) | 23 (76.7) | 9 (30.0) | 14 (46.7) | 0.400 |
Positive urine cytology, n (%) | 17 (56.6) | 4 (13.3) | 13 (43.3) | 0.012 |
Creatinine (mg/dL), median (IQR) | 1.1 (0.9–1.5) | 1.4 (1.0–1.7) | 1.1 (0.9–1.4) | 0.346 |
Hemoglobin (ng/mL), median (IQR) | 12.8 (11.9–14.2) | 13.1 (12.6–14.3) | 12.5 (11.9–13.2) | 0.225 |
Presence of multifocal diseases, n (%) | 14 (46.7) | 6 (20.0) | 8 (26.7) | 0.961 |
Radiological features (per lesion) | ||||
Sample size, n (%) | 39 (100) | 17 (43.6) | 22 (56.4) | - |
Morphology | ||||
Sessile, n (%) | 36 (92.3) | 16 (41.0) | 20 (51.3) | 0.210 |
Papillary, n (%) | 3 (7.7) | 1 (2.6) | 2 (5.1) | |
MR suspicion of muscle invasion, n (%) | ||||
Yes | 26 (66.7) | 5 (12.8) | 21 (53.8) | < 0.001 |
No | 13 (33.3) | 12 (30.8) | 1 (2.6) | |
Excretory tract stenosis n (%) | ||||
No | 8 (20.5) | 2 (5.1) | 6 (15.4) | 0.178 |
Present, < 50% | 7 (17.9) | 5 (12.8) | 2 (5.1) | 0.020 |
Present, ≥ 50%, < 75% | 9 (23.1) | 4 (10.3) | 5 (12.8) | 0.907 |
Present, ≥ 75% | 15 (38.5) | 6 (15.4) | 9 (23.1) | 0.542 |
MR suspicion of perivisceral fat infiltration, n (%) | ||||
Yes | 9 (23.1) | 0 (0) | 9 (23.1) | < 0.001 |
No | 30 (76.9) | 30 (76.9) | 0 (0) | |
Adjacent organs infiltration, n (%) | 1 (2.6) | 0 (0) | 1 (2.6) | 0.348 |
Hydronephrosis, n (%) | ||||
No | 10 (25.6) | 5 (12.8) | 5 (12.8) | 0.777 |
1 grade | 7 (17.9) | 3 (7.7) | 3 (7.7) | 0.847 |
2 grade | 9 (23.1) | 3 (7.7) | 7 (17.9) | 0.159 |
3 grade | 10 (25.6) | 4 (10.3) | 6 (15.4) | 0.308 |
4 grade | 3 (7.6) | 2 (5.1) | 1 (2.6) | 0.643 |
Kidney atrophy, n (%) | 4 (10.3) | 2 (5.1) | 2 (5.1) | 0.871 |
MR suspicion of nodes involvement, n (%) | 9 (23.1) | 1 (2.6) | 8 (20.5) | < 0.001 |
Surgical and pathological features (per lesion) | ||||
Sample size, n (%) | 39 (100) | 18 (46.2) | 21 (53.8) | - |
Primary tumor stage (pT) | ||||
0 | 1 (2.6) | 1 (2.6) | - | - |
A | 6 (15.4) | 6 (15.4) | - | |
IS | 1 (2.6) | 1 (2.6) | - | |
1 | 10 (25.6) | 10 (25.6) | - | |
2 | 12 (30.8) | - | 12 (30.8) | |
3 | 8 (20.5) | - | 8 (20.5) | |
4 | 1 (2.6) | - | 1 (2.6) | |
Tumor grade | ||||
Low | 15 (38.5) | 10 (25.6) | 5 (12.8) | 0.042 |
High | 24 (61.5) | 8 (20.5) | 16 (41.0) | |