Fig. 3

Synchrotron radiation computed microtomography-based analysis of the notable structural features. a B1 acquired specimens demonstrate a significantly higher volume compared to control, a large variability in volumes can be noted in all tested bioptomes (**p = 0.0013). b B2 displays a significantly higher compression score than the control bioptome while B1 scores comparably to control (**p = 0.0011). c Inner integrity ratio estimates the amount of rupture inside the biopsied tissue (approaching 1.00 = less rupture), the structure of the of B1 samples was comparable to the control samples, while B2 obtained samples show a comparably low integrity (**p = 0.0091). d Outer integrity ratio estimates the amount of surface roughness on the biopsy, produced by the expulsion of the bioptome after the cut was performed (approaching 1.00 = less rupture). B1 specimens show a comparable outer integrity to the control biopsies while B2 has significantly lower outer integrity (*p = 0.0320). Statistical significance was determined by Mann–Whitney U test, assuming non-Gaussian distribution, n = 18, 18, and 6 for B1, B2, and control samples