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European Radiology Experimental
Fig. 2 | European Radiology Experimental

Fig. 2

From: Interval between contrast administration and T1-weighted MRI for cerebral adrenoleukodystrophy: a single-case observation

Fig. 2

Variation of contrast enhancement detection on different T1-weighted sequences at different time points in the same adrenoleukodystrophy patient shown in Fig. 1. a, top row: no contrast enhancement is visible on the T1-weighted three-dimensional (3D) gradient-echo sequence before and 6, 12, and 36 min after gadobutrol administration. a, bottom row: the T1-weighted two-dimensional (2D) gradient-echo sequence before and 6, 12, and 36 min after gadobutrol administration show the presence of contrast enhancement from 6 minutes on; the arrows indicate the areas of enhancement on the 6-min image. b Signal intensity variation, expressed as percentage of its maximum value, is plotted against time for the T1-weighted 2D gradient-echo sequence as average of the two regions of interest (ROIs) drawn on the precontrast image of the 3D series (one ROI in the frontal lobes, considering two blue areas; one ROI in the parietal lobes, considering two red areas) to allow a clean evaluation of the 2D series

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