Contrast-enhanced mammography (CEM) versus MRI for breast cancer staging: detection of additional malignant lesions not seen on conventional imaging

European Radiology Experimental

Table 3 Features of the six additional malignant lesions

Variable	Lesion 1	Lesion 2	Lesion 3	Lesion 4	Lesion 5	Lesion 6
CEM BPE	Mild	Minimal	Minimal	Minimal	Mild	Minimal
MRI BPE	Mild	Mild	Minimal	Mild	Moderate	Minimal
MRI NBCC score	3	3	3	3	3	5
CEM finding	None	None	None	None	None^d	Mass
CEM lesion enhancement relative to background	None	None	None	None	None	Moderate
CEM size (mm)	−	−	−	−	−	12
CEM NBCC score	−	−	−	−	−	3
MRI finding	Mass	Non-mass	Mass	Focus	Mass	Mass
MRI lesion enhancement relative to background	High	Low	Low	High	Low	High
MRI size (mm)	7	34	5	5	6	12
Histological type	IDC	DCIS	DCIS	IDC and DCIS	Metastatic lymph node (from ILC)	IDC, ILC, and DCIS
Tumour grade	2	Low	High	2	3^a	1 and 2
Oestrogen receptor	Positive	Not done	Not done	Positive	Positive^a	Positive
Progesterone receptor	Positive	Not done	Not done	Positive	Positive^a	Positive
Her2/Neu	Positive	Not done	Not done	Negative	Negative^a	Negative
Intrinsic subtype	Luminal B-like (Her2/Neu positive)	Not available	Not available	Luminal A-like	Luminal B-like^a	Luminal A-like
Lesion size on pathology (mm)	7	30	2	7	− ^c	15

Six additional malignant lesions were found in six different patients; all were in a breast already known to contain malignant lesion(s) detected by mammography and/or ultrasound. ^aThese values are those of the index malignant lesion. ^cSize not recorded. ^dLesion out of the field of view of CEM. BPE Background parenchymal enhancement, CEM Contrast-enhanced mammography, DCIS Ductal carcinoma in situ, HER2/Neu Human epidermal growth factor receptor 2, IDC Invasive ductal carcinoma, ILC Invasive lobular carcinoma, MRI Magnetic resonance imaging