Fig. 4

Assessment of activity in the open-field test. a The upper graphs show the running distance every 5 min for a total of 20 min. ^###p < 0.001 by two-way repeated ANOVA comparing the control and whole-brain irradiation (WBI) groups (n = 16−18). N.S. stands for no significant difference by two-way ANOVA comparing the control and cerebellar irradiation groups (n = 9−12). The lower graphs show the distance run over 20 min. ** p < 0.01 by unpaired two-tailed Student t-test comparing the control and WBI groups (n = 16−18). N.S. stands for no significant difference by unpaired two-tailed Student t-test comparing the control and cerebellar irradiation alone (CIA) groups (n = 10−12). b The upper graph shows the activity every 5 min for a total of 20 min. ^###p < 0.001 by two-way ANOVA comparing the control and WBI groups (n = 16–18). N.S. stands for no significant difference by two-way ANOVA comparing the control and CIA groups (n = 9−12). The lower graphs show the distance run over 20 min. *p < 0.05 by unpaired two-tailed Student t-test comparing the control and WBI groups (n = 16−18). N.S. stands for no significant difference by unpaired two-tailed Student t-test comparing the control and CIA groups (n = 10−12). For all graphs, the data are presented as the mean ± standard error of the mean. IR, Irradiation.