Fig. 1

Lesion and disconnectome maps. T1-weighted hypointense lesion (red) and disconnectome (blue) maps obtained in two patients involved in the study are shown on the Montreal Neurological Institute 152 template. Axial plane (a): a little lesion in the genu of internal capsule (red) leads to a more extensive white matter bundle disconnection involving the entire anterior arm of internal capsule (blue). Coronal plane (b): multiple lesions in periventricular areas (red) lead to a very extensive white matter bundle disconnection (blue), especially in the corpus callosum