Myocardial CT perfusion imaging for the detection of obstructive coronary artery disease: multisegment reconstruction does not improve diagnostic performance

European Radiology Experimental

Table 5 Patient subgroups in per-territory level analysis: diagnostic performance of MSR and HSR of myocardial CTP

	Patients with known CAD			Patients with suspected CAD			Patients with high heart rates ≥ 75 bpm			Patients with low heart rates < 75 bpm
Reconstruction/performance	HSR	MSR	p-value	HSR	MSR	p-value	HSR	MSR	p-value	HSR	MSR	p-value
Area under the curve^a	0.86 [0.81, 0.91]	0.72 [0.65, 0.79]	< 0.001	0.93 [0.87, 0.99]	0.71 [0.55, 0.87]	0.002	0.89 [0.83, 0.95]	0.74 [0.63, 0.85]	< 0.001	0.87 [0.82, 0.92]	0.70 [0.62, 0.78]	< 0.001
Sensitivity	78 (56/72) [66, 87]	49 (35/72) [37, 61]	< 0.001	86 (12/14) [57, 98]	57 (8/14) [29, 82]	0.134	90 (27/30) [73, 98]	60 (18/30) [41, 77]	0.008	73 (41/56) [60, 84]	45 (25/56) [31, 59]	< 0.001
Specificity	83 (119/143) [76, 89]	90 (128/143) [83, 94]	0.039	83 (52/63) [71, 91]	81 (51/63) [69, 90]	0.999	78 (49/63) [66, 87]	83 (52/63) [71, 91]	0.371	85 (122/143) [78, 91]	89 (127/143) [82, 93]	0.302
Positive predictive value	70 (56/80) [59, 80]	70 (35/50) [55, 82]	0.999	52 (12/23) [31, 73]	40 (8/20) [19, 62]	0.078	66 (27/41) [49, 80]	62 (18/29) [42, 79]	0.475	66 (41/62) [53, 78]	61 (25/41) [45, 76]	0.381
Negative predictive value	88 (119/135) [81, 93]	78 (128/165) [70, 84]	< 0.001	96 (52/54) [87, 100]	89 (51/57) [78, 96]	0.037	94 (49/52) [84, 99]	81 (52/64) [70, 90]	0.002	89 (122/137) [83, 94]	80 (127/158) [73, 86]	< 0.001

Reference: ≥ 50% diameter vessel stenosis detected in quantitative invasive coronary angiography. Data are the results of consensus reading of two readers. Unless otherwise stated, data are percentages, data in parentheses are raw data, and data in brackets are 95% confidence intervals. The 95% confidence intervals were estimated for unclustered data (see reference [31]). ^aData are the area under the curve and data in brackets are 95% confidence intervals. bpm Beats per minute, CAD Coronary artery disease, CTP Computed tomography perfusion, HSR Halfscan reconstruction, MSR Multisegment reconstruction