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Table 5 Patient subgroups in per-territory level analysis: diagnostic performance of MSR and HSR of myocardial CTP

From: Myocardial CT perfusion imaging for the detection of obstructive coronary artery disease: multisegment reconstruction does not improve diagnostic performance

  Patients with known CAD Patients with suspected CAD Patients with high heart rates ≥ 75 bpm Patients with low heart rates < 75 bpm
Reconstruction/performance HSR MSR p-value HSR MSR p-value HSR MSR p-value HSR MSR p-value
Area under the curvea 0.86 [0.81, 0.91] 0.72 [0.65, 0.79] < 0.001 0.93 [0.87, 0.99] 0.71 [0.55, 0.87] 0.002 0.89 [0.83, 0.95] 0.74 [0.63, 0.85] < 0.001 0.87 [0.82, 0.92] 0.70 [0.62, 0.78] < 0.001
Sensitivity 78 (56/72) [66, 87] 49 (35/72) [37, 61] < 0.001 86 (12/14) [57, 98] 57 (8/14) [29, 82] 0.134 90 (27/30) [73, 98] 60 (18/30) [41, 77] 0.008 73 (41/56) [60, 84] 45 (25/56) [31, 59] < 0.001
Specificity 83 (119/143) [76, 89] 90 (128/143) [83, 94] 0.039 83 (52/63) [71, 91] 81 (51/63) [69, 90] 0.999 78 (49/63) [66, 87] 83 (52/63) [71, 91] 0.371 85 (122/143) [78, 91] 89 (127/143) [82, 93] 0.302
Positive predictive value 70 (56/80) [59, 80] 70 (35/50) [55, 82] 0.999 52 (12/23) [31, 73] 40 (8/20) [19, 62] 0.078 66 (27/41) [49, 80] 62 (18/29) [42, 79] 0.475 66 (41/62) [53, 78] 61 (25/41) [45, 76] 0.381
Negative predictive value 88 (119/135) [81, 93] 78 (128/165) [70, 84] < 0.001 96 (52/54) [87, 100] 89 (51/57) [78, 96] 0.037 94 (49/52) [84, 99] 81 (52/64) [70, 90] 0.002 89 (122/137) [83, 94] 80 (127/158) [73, 86] < 0.001
  1. Reference: ≥ 50% diameter vessel stenosis detected in quantitative invasive coronary angiography. Data are the results of consensus reading of two readers. Unless otherwise stated, data are percentages, data in parentheses are raw data, and data in brackets are 95% confidence intervals. The 95% confidence intervals were estimated for unclustered data (see reference [31]). aData are the area under the curve and data in brackets are 95% confidence intervals. bpm Beats per minute, CAD Coronary artery disease, CTP Computed tomography perfusion, HSR Halfscan reconstruction, MSR Multisegment reconstruction