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Table 4 Patient subgroups in per-patient level analysis: diagnostic performance of MSR and HSR of myocardial CTP

From: Myocardial CT perfusion imaging for the detection of obstructive coronary artery disease: multisegment reconstruction does not improve diagnostic performance

  Patients with known CAD Patients with suspected CAD Patients with high heart rates ≥ 75 bpm Patients with low heart rates < 75 bpm
Reconstruction/performance HSR MSR p-value HSR MSR p-value HSR MSR p-value HSR MSR p-value
Area under the curvea 0.72 [0.57, 0.86] 0.62 [0.45, 0.79] 0.157 0.89 [0.77, 1.00] 0.80 [0.63, 0.97] 0.243 0.55 [0.33, 0.77] 0.54 [0.27, 0.81] 0.611 0.87 [0.78, 0.95] 0.70 [0.57, 0.83] 0.007
Sensitivity 86 (43/50) [73, 94] 62 (31/50) [47, 75] 0.001 100 (8/8) [63, 100] 100 (8/8) [63, 100] 1.000 90 (19/21) [70, 99] 86 (18/21) [64, 97] 0.999 86 (32/37) [71, 95] 57 (21/37) [39, 73] 0.003
Specificity 39 (7/18) [17, 64] 67 (12/18) [41, 87] 0.131 59 (10/17) [33, 82] 65 (11/17) [38, 86] 0.999 11 (1/9) [0, 48] 33 (3/9) [7, 70] 0.480 62 (16/26) [41, 80] 77 (20/26) [56, 91] 0.289
Positive predictive value 80 (43/54) [66, 89] 84 (31/37) [68, 94] 0.387 53 (8/15) [27, 79] 57 (8/14) [29, 82] 0.563 70 (19/27) [50, 86] 75 (18/24) [53, 90] 0.254 76 (32/42) [61, 88] 78 (21/27) [58, 91] 0.814
Negative predictive value 50 (7/14) [23, 77] 39 (12/31) [22, 58] 0.282 100 (10/10) [69, 100] 100 (11/11) [72, 100] 0.999 33 (1/3) [1, 91] 50 (3/6) [12, 88] 0.417 76 (16/21) [53, 92] 56 (20/36) [38, 72] 0.009
  1. Reference: ≥ 50% diameter vessel stenosis detected in quantitative invasive coronary angiography. Data are the results of consensus reading of two readers. Unless otherwise stated, data are percentages, data in parentheses are raw data, and data in brackets are 95% confidence intervals. The 95% confidence intervals were estimated for unclustered data (see reference [31]). aData are the area under the curve and data in brackets are 95% confidence intervals. bpm Beats per minute, CAD Coronary artery disease, CTP Computed tomography perfusion, HSR Halfscan reconstruction, MSR Multisegment reconstruction