Myocardial CT perfusion imaging for the detection of obstructive coronary artery disease: multisegment reconstruction does not improve diagnostic performance

European Radiology Experimental

Table 4 Patient subgroups in per-patient level analysis: diagnostic performance of MSR and HSR of myocardial CTP

	Patients with known CAD			Patients with suspected CAD			Patients with high heart rates ≥ 75 bpm			Patients with low heart rates < 75 bpm
Reconstruction/performance	HSR	MSR	p-value	HSR	MSR	p-value	HSR	MSR	p-value	HSR	MSR	p-value
Area under the curve^a	0.72 [0.57, 0.86]	0.62 [0.45, 0.79]	0.157	0.89 [0.77, 1.00]	0.80 [0.63, 0.97]	0.243	0.55 [0.33, 0.77]	0.54 [0.27, 0.81]	0.611	0.87 [0.78, 0.95]	0.70 [0.57, 0.83]	0.007
Sensitivity	86 (43/50) [73, 94]	62 (31/50) [47, 75]	0.001	100 (8/8) [63, 100]	100 (8/8) [63, 100]	1.000	90 (19/21) [70, 99]	86 (18/21) [64, 97]	0.999	86 (32/37) [71, 95]	57 (21/37) [39, 73]	0.003
Specificity	39 (7/18) [17, 64]	67 (12/18) [41, 87]	0.131	59 (10/17) [33, 82]	65 (11/17) [38, 86]	0.999	11 (1/9) [0, 48]	33 (3/9) [7, 70]	0.480	62 (16/26) [41, 80]	77 (20/26) [56, 91]	0.289
Positive predictive value	80 (43/54) [66, 89]	84 (31/37) [68, 94]	0.387	53 (8/15) [27, 79]	57 (8/14) [29, 82]	0.563	70 (19/27) [50, 86]	75 (18/24) [53, 90]	0.254	76 (32/42) [61, 88]	78 (21/27) [58, 91]	0.814
Negative predictive value	50 (7/14) [23, 77]	39 (12/31) [22, 58]	0.282	100 (10/10) [69, 100]	100 (11/11) [72, 100]	0.999	33 (1/3) [1, 91]	50 (3/6) [12, 88]	0.417	76 (16/21) [53, 92]	56 (20/36) [38, 72]	0.009

Reference: ≥ 50% diameter vessel stenosis detected in quantitative invasive coronary angiography. Data are the results of consensus reading of two readers. Unless otherwise stated, data are percentages, data in parentheses are raw data, and data in brackets are 95% confidence intervals. The 95% confidence intervals were estimated for unclustered data (see reference [31]). ^aData are the area under the curve and data in brackets are 95% confidence intervals. bpm Beats per minute, CAD Coronary artery disease, CTP Computed tomography perfusion, HSR Halfscan reconstruction, MSR Multisegment reconstruction