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Table 2 Cox regression analysis for overall survival with a restricted 2-year follow-up

From: Automated artificial intelligence-based analysis of skeletal muscle volume predicts overall survival after cystectomy for urinary bladder cancer

 

Univariable

Multivariable model 1

Multivariable model 2

 

HR (95% CI)

p

HR (95% CI)

p

HR (95% CI)

p

Age, years

1.01 (0.98–1.03)

0.676

    

Sex male

1.18 (0.72–1.93)

0.512

    

Smoking

1.09 (0.66–1.81)

0.728

    

ASA score 3–4

2.18 (1.45–3.28)

< 0.001

2.35 (1.56–3.55)

< 0.001

2.47 (1.63–3.73)

< 0.001

cT stage 2–4

3.15 (1.91–5.21)

< 0.001

3.24 (1.96–5.37)

< 0.001

3.50 (2.11–5.81)

< 0.001

Neoadjuvant chemotherapy

1.19 (0.62–2.29)

0.608

    

Previous pelvic surgery or radiotherapy

1.08 (0.68–1.70)

0.747

    

Muscle volume below median

1.66 (1.10–2.50)

0.016

1.62 (1.07–2.44)

0.022

  

Muscle volume

      

Quartile 4

1 (ref)

   

1 (ref)

 

Quartile 3

0.93 (0.49–1.76)

0.821

  

0.99 (0.52–1.87)

0.964

Quartile 2

1.24 (0.68–2.26)

0.480

  

1.12 (0.62–2.05)

0.704

Quartile 1

1.99 (1.14–3.46)

0.015

  

2.26 (1.30–3.95)

0.004

  1. ASA score was dichotomised 1–2 versus 3–4. cT stage was dichotomised muscle invasive versus noninvasive. Muscle volumes were dichotomised higher versus lower than median values, and grouped into quartiles, for men and women separately. ASA American Society of Anesthesiologists, CI Confidence interval, cT Clinical local tumour stage, HR Hazard ratio