Concentrations and pharmacokinetic parameters of MRI and SPECT hepatobiliary agents in rat liver compartments

European Radiology Experimental

Table 1 Bopta and Meb concentrations (end of accumulation period)

Imaging agents	Bopta	Meb	p, Bopta *versus* Meb	Bopta
Livers	Normal	Normal		no Mrp2
C_in [μM]	200	64		200
C_out [μM]	185 ± 2	5 ± 2	< 0.001	186 ± 3^ns
C_EC [μM]	60 ± 10	31 ± 7	< 0.001	52 ± 16^ns
C_BC [μM]	66 ± 11	393 ± 61	< 0.001	3 ± 1**
C_HC78% [μM]	360 ± 69	2,043 ± 333	< 0.001	804 ± 185**
C_HC100% [μM]	462 ± 88	2,619 ± 427	< 0.001	1,031 ± 237**
C_bile [μM]	15,734 ± 2,380	94,529 ± 9,759	< 0.001	713 ± 171**

Statistics between normal livers and livers lacking Mrp2 perfused with Bopta (column 2 versus column 5) are nonsignificant (ns) and p < 0.001 (**). C_EC Concentration in extracellular space, C_BC Concentration in bile canaliculi detected by the counter, C_bile In situ concentration in bile canaliculi and common bile duct, C_HC78% Concentration in hepatocytes detected by the counter, C_HC100% In situ hepatocyte concentrations