Fig. 2

Bopta and Meb compartmental distribution. a Normal livers (n = 9) perfused with Krebs-Henseleit bicarbonate solution (KHB) + 200 μM Bopta (45–75 min) and KHB (75–105 min). b Normal livers (n = 9) perfused with KHB + 64 μM Meb (45–75 min) and KHB (75–105 min). c Cholestatic livers lacking Mrp2 (n = 6) perfused with KHB + 200 μM Bopta (45–75 min) and KHB (75–105 min). Liver concentrations (black symbols) are measured by the counter. Concentrations in extracellular compartment (red symbols) are measured during the previous Dtpa perfusion (data not shown). Concentrations that originate from bile canaliculi (blue symbols) and from 78% hepatocytes (green symbols) are calculated