Impact of inter-reader contouring variability on textural radiomics of colorectal liver metastases

European Radiology Experimental

Table 4 Mean relative changes and intraclass correlation coefficients are reported for all the textural features and both the 2D and 3D ROI sets

		2D ROI		3D ROI
		Relative change	ICC	Relative change	ICC
GLRLM	GLNU	16%	0.34	21%	0.20
	HGLRE	7%	0.95	8%	0.69
	LRE	5%	0.99	4%	0.99
	LRHGLE	8%	0.98	7%	0.99
	LRLGLE	8%	0.99	9%	0.96
	LGLRE	7%	0.93	9%	0.46
	RLNU	6%	0.99	5%	0.99
	Run percentage	2%	0.99	2%	0.99
	SRE	3%	0.98	2%	0.99
	SRHGLE	7%	0.96	9%	0.83
	SRLGLE	10%	0.73	9%	0.61
GLCM	AutoCorrelation	7%	0.70	7%	0.74
	Cluster prominence	418%	0.06	641%	0.08
	ClusterShade	752%	0.13	1567%	0.06
	Cluster tendency	100%	0.20	116%	0.20
	Contrast	13%	0.95	22%	0.89
	Correlation	30%	0.49	57%	0.35
	Difference entropy	3%	0.96	6%	0.90
	Dissimilarity	5%	0.97	9%	0.93
	Energy	23%	0.77	25%	0.64
	Entropy	10%	0.76	11%	0.66
	Homogeneity	1%	0.98	2%	0.96
	Homogeneity2	2%	0.98	3%	0.95
	InformationMeasureCorrel1	65%	0.62	136%	0.48
	InformationMeasureCorrel2	22%	0.49	46%	0.35
	InverseDifferMomentNormal	0%	0.95	0%	0.89
	InverseDifferNormal	0%	0.97	0%	0.94
	InverseVariance	1%	0.96	2%	0.88
	MaxProbability	19%	0.82	21%	0.74
	SumAverage	3%	0.73	3%	0.76
	SumEntropy	12%	0.45	14%	0.34
	SumVariance	6%	0.80	6%	0.84

Bold text is used for features found robust against inter-reader variability (ICC > 0.90 and mean relative change < 10%)
2D Two dimensional, 3D Three dimensional, GLCM Grey level co-occurrence matrix, GLNU Grey level non-uniformity, GLRLM Grey level run length matrix, HGLRE High grey level run emphasis, ICC Intraclass correlation coefficient, LGLRE Low grey level run emphasis, LRE Long run emphasis, LRHGLE Long run high grey level emphasis, LRLGLE Long run low grey level emphasis, RLNU Run length non-uniformity, SRE Short run emphasis, SRHGLE Short run high grey level emphasis, SRLGLE Short run low grey level emphasis.