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Table 4 Radiological-pathological comparisons and expected outcomes

From: 7-T MRI of explanted liver and ex-vivo pancreatic specimens: prospective study protocol of radiological-pathological correlation feasibility (the EXLIPSE project)

Analysis Imaging investigated Pathological reference Expected outcomes
Qualitative analyses
 1. Image consistency CUBE
IDEAL T1w
IDEAL T2w
IDEAL Fat-water
2D MRCP
3D MRCP
MP2RAGE
MSE
3D MRF
2D MRF
Histological confirmation of the presence and type of lesion/tissue alteration identified by imaging Diagnostic reliability using morphological sequences
Quantitative analyses
 1. T1 relaxation time values of cirrhotic liver parenchyma
 2. T1 relaxation time value of hepatic lesions
 3. T1 relaxation time value of pancreatic lesion
MP2RAGE
3D MRF (T1-map)
2D MRF (T1-map)
1. Fibrotic/regenerative characteristics of the liver tissue
2. Focal lesions affecting the cirrhotic liver
3. Pancreatic lesion characteristics
1. Correlation between the fibrotic degree and the T1-value
2. Differential diagnosis of the focal hepatic lesions based on T1-value
3. Pancreatic lesion stroma related to T1-value
 1. T2 relaxation time values of hepatic lesions
 2. T2 relaxation time value of pancreatic lesion
MSE
3D MRF (T2-map)
1. Focal lesions affecting the cirrhotic liver
2. Pancreatic lesion characteristics
1. Differential diagnosis of the focal hepatic lesions based on T2-value
2. Pancreatic lesion aggressiveness related to T2-value
Fat-fraction values of steatotic liver parenchyma IDEAL Fat-water
2D MRF (fat-fraction and water-fraction)
3D MRF (fat-fraction and water-fraction)
Well-established histological classification of the steatosis distribution Good radiological-pathological correlation about the degree of steatosis
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