Fig. 3

Receiver operating characteristic analysis for assessing the ability of tumour volume changes measured by micro-CT, CT, and MRI to discriminate between mice that received treatment and mice that received sham (a) or no treatment (b). Areas under the curve (AUC) were significant for all three modalities. a Cisplatin versus phosphate-buffered saline: micro-CT (blue line), AUC 0.902, p < 0.001; CT (red dashed line), AUC 1.0, p < 0.001; MRI (green dashed line), AUC 0.992, p < 0 .001. b Cisplatin versus no treatment: micro-CT (blue line), AUC 0.944, p = 0.001; CT (red dashed line), AUC 0.967, p = 0.001; MRI (green dashed line), AUC 0.933, p = 0.001). CT, Computed tomography; MRI, Magnetic resonance imaging