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European Radiology Experimental

Table 3 In vivo Ho recovery in subcutaneous VX-2 tumour-bearing rabbits by single-photon emission computed tomography (SPECT) and computed tomography (CT)

From: Feasibility of CT quantification of intratumoural 166Ho-microspheres

Rabbit

Injected Ho

Tumour volume

Volume of voxels with HU > 100

CT recovery

SPECT recovery

 

MBq

mg

cm3

cm3

%

mg

%

MBq

%

1

0.10

3.6

6.6

0.5

6.9

2.8

77.7

NP

2

0.07

2.2

6.0

0.2

3.5

1.3

59.9*

NP

3

0.04

1.4

7.2

0.2

3.2

1.1

76.9

NP

4

0.01

0.4

3.2

0.1

2.5

0.4

100.0

NP

5

57.9

2.9

3.4

0.3

9.1

1.9

65.4*

54.3

93.8%

  1. Five rabbits with subcutaneous VX-2 tumours were injected with decayed or radioactive microspheres with the corresponding amounts of Ho. The tumour volume ranged from 3.2 to 7.2 cm3, based on the HU < 100 threshold while 0.1–0.5 cm3 or 2.5–9.1% of the tumour volume was filled with holmium after treatment. Ho recovery by CT ranged from 59.9 to 100.0% (n = 5), recovery by SPECT was 93.8% (n = 1)
  2. NP Not performed
  3. *Evident collections of air on CT resulting in decreased recovery of holmium due to partial volume effects and voxels with large negative HU
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