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Table 1 Semiquantitative histology scores

From: Prospective study to assess the tissue response to HPC-coated p48 flow diverter stents compared to uncoated devices in the rabbit carotid artery model

AttributeScoreDescription of assigned score
Injury score0No injury
1< 25% of the vessel circumference showing disruption of the EEL, IEL, or media respectively
225–50% of the vessel circumference showing disruption of the EEL, IEL, or media respectively
3> 50% of the vessel circumference showing disruption of the EEL, IEL, or media respectively
Thrombus
(platelets/fibrin)
0None
1Minimal focal
2Mild multifocal
3Moderate regionally diffuse
4Severe marked diffuse total occlusion
Neointimal/medial fibrin deposition0None to focal interstitial fibrin minimal spotting of fibrin generally consistent with background levels
1< 10% of circumference showing interstitial fibrin
210–25% of circumference showing interstitial fibrin
3> 25% of the circumference showing interstitial fibrin
Red blood cell extravasation score0No red blood cell extravasation
1< 25% red blood cell extravasation
225–50% red blood cell extravasation showing disruption of the EEL, IEL, and media, respectively
3> 50% red blood cell extravasation
Calcification0None
1Focal with < 10% of the region affected
2Multifocal with 10–25% of the region affected
3Regionally diffuse with 26–30% of the region affected
4Regionally diffuse with > 30% of the region affected
Endothelial loss0None
1< 25% of the circumference
225–50% of the circumference
351–75% of the circumference
4> 75% of the circumference
Adventitial inflammation score0No inflammation to minimal interspersed inflammatory cells
1Mild peripheral inflammatory infiltration or focally moderated in < 25% of adventitial area
2Moderate peripheral inflammatory infiltration or focally marked in 25–50% of adventitial area
3Heavy peripheral inflammatory infiltration or focally marked in > 50% of adventitial area
  1. Vessel wall injury was defined as a break in the arterial wall structures: external elastic lamina (EEL); internal elastic lamina (IEL); media. Neointimal fibrin deposition was defined as interstitial fibrin with or without associated stent mesh