| |
Partial response (n = 30)
|
Stable disease (n = 20)
|
Progressive disease (n = 3)
|
|---|
|
Baseline
|
Control
|
p value
|
Baseline
|
Control
|
p value
|
Baseline
|
Control
|
p value
|
|---|
|
Blood flow (mL/100 mL/min)
|
162.0 ± 78.8
|
154.7 ± 90.2
|
0.681
|
234.0 ± 199.0
|
195.3 ± 111.8
|
0.391
|
171.7 ± 146.2
|
170.41 ± 130.3
|
0.968
|
|
Blood volume (mL/100 mL)
|
8.1 ± 3.1
|
6.4 ± 3.0
|
0.006
|
9.3 ± 4.9
|
7.9 ± 3.7
|
0.137
|
7.3 ± 2.8
|
7.3 ± 4.8
|
0.975
|
|
Permeability (mL/100 mL/min)
|
15.5 ± 5.7
|
13.9 ± 8.3
|
0.307
|
17.8 ± 11.3
|
16.5 ± 10.2
|
0.709
|
18.3 ± 6.5
|
17.7 ± 9.6
|
0.809
|
|
Mean transit time (s)
|
7.1 ± 3.1
|
5.8 ± 2.4
|
0.031
|
6.4 ± 4.1
|
5.8 ± 2.3
|
0.456
|
7.8 ± 3.5
|
7.0 ± 3.6
|
0.465
|
|
RECIST-1.1 diameter (mm)
|
59.8 ± 23.7
|
41.0 ± 18.0
|
0.000
|
55.7 ± 23.4
|
53.3 ± 23.2
|
0.007
|
58.7 ± 20.4
|
65.0 ± 26.2
|
0.210
|
|
Tumour volume (cc)
|
120.2 ± 154.0
|
44.6 ± 59.8
|
0.000
|
90.4 ± 122.3
|
64.3 ± 108.0
|
0.006
|
93.3 ± 73.4
|
126.7 ± 97.6
|
0.145
|
- Significant p values are in bold
- RECIST Response evaluation criteria in solid tumours
