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Table 1 General characteristic of different groups of CCL4 rats

From: Quantification of liver fibrosis: extracellular volume fraction using an MRI bolus-only technique in a rat animal model

Parameter

Control (n = 10)

8-week CCl4 (n = 10)

16-week CCL4 (n = 13)

p value

Body weight (g)

488.0 ± 81.1

368.7 ± 45.7*

499.3 ± 54.8#

< 0.001

Liver weight (g)

15.3 ± 2.7

14.6 ± 2.3

17.2 ± 2.8

0.081

Mean arterial pressure (mmHg)

113.4 ± 16.4

103.9 ± 22.7

102.5 ± 21.4

0.287

Portal pressure (mmHg)

9.0 ± 1.3

15.0 ± 2.6*

19.1 ± 7.5*

< 0.001

Positive staining Sirius red (%)

0.1 ± 0.1

3.3 ± 2.6*

25.1 ± 3.2*#

< 0.001

Native T1 relaxation time (ms)

593.3 ± 10.3

625.5 ± 38.3

645.6 ± 41.0*

0.007

5 min extracellular volume fraction (%)

17.8 ± 2.4

23.5 ± 4.8

29.1 ± 3.5*

< 0.001

15 min extracellular volume fraction (%)

18.0 ± 3.0

23.6 ± 4.8

30.5 ± 3.3*#

< 0.001

25 min extracellular volume fraction (%)

18.3 ± 3.0

23.7 ± 4.7

31.2 ± 2.4*#

< 0.001

  1. Data are presented as mean ± standard deviation. CCl4 carbon tetrachloride. * p < 0.05 versus control; # p < 0.05 versus 8-week CCl4