Parameter | Control (n = 10) | 8-week CCl4 (n = 10) | 16-week CCL4 (n = 13) | p value |
---|---|---|---|---|
Body weight (g) | 488.0 ± 81.1 | 368.7 ± 45.7* | 499.3 ± 54.8# | < 0.001 |
Liver weight (g) | 15.3 ± 2.7 | 14.6 ± 2.3 | 17.2 ± 2.8 | 0.081 |
Mean arterial pressure (mmHg) | 113.4 ± 16.4 | 103.9 ± 22.7 | 102.5 ± 21.4 | 0.287 |
Portal pressure (mmHg) | 9.0 ± 1.3 | 15.0 ± 2.6* | 19.1 ± 7.5* | < 0.001 |
Positive staining Sirius red (%) | 0.1 ± 0.1 | 3.3 ± 2.6* | 25.1 ± 3.2*# | < 0.001 |
Native T1 relaxation time (ms) | 593.3 ± 10.3 | 625.5 ± 38.3 | 645.6 ± 41.0* | 0.007 |
5 min extracellular volume fraction (%) | 17.8 ± 2.4 | 23.5 ± 4.8 | 29.1 ± 3.5* | < 0.001 |
15 min extracellular volume fraction (%) | 18.0 ± 3.0 | 23.6 ± 4.8 | 30.5 ± 3.3*# | < 0.001 |
25 min extracellular volume fraction (%) | 18.3 ± 3.0 | 23.7 ± 4.7 | 31.2 ± 2.4*# | < 0.001 |