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Table 1 General characteristic of different groups of CCL4 rats

From: Quantification of liver fibrosis: extracellular volume fraction using an MRI bolus-only technique in a rat animal model

Parameter Control (n = 10) 8-week CCl4 (n = 10) 16-week CCL4 (n = 13) p value
Body weight (g) 488.0 ± 81.1 368.7 ± 45.7* 499.3 ± 54.8# < 0.001
Liver weight (g) 15.3 ± 2.7 14.6 ± 2.3 17.2 ± 2.8 0.081
Mean arterial pressure (mmHg) 113.4 ± 16.4 103.9 ± 22.7 102.5 ± 21.4 0.287
Portal pressure (mmHg) 9.0 ± 1.3 15.0 ± 2.6* 19.1 ± 7.5* < 0.001
Positive staining Sirius red (%) 0.1 ± 0.1 3.3 ± 2.6* 25.1 ± 3.2*# < 0.001
Native T1 relaxation time (ms) 593.3 ± 10.3 625.5 ± 38.3 645.6 ± 41.0* 0.007
5 min extracellular volume fraction (%) 17.8 ± 2.4 23.5 ± 4.8 29.1 ± 3.5* < 0.001
15 min extracellular volume fraction (%) 18.0 ± 3.0 23.6 ± 4.8 30.5 ± 3.3*# < 0.001
25 min extracellular volume fraction (%) 18.3 ± 3.0 23.7 ± 4.7 31.2 ± 2.4*# < 0.001
  1. Data are presented as mean ± standard deviation. CCl4 carbon tetrachloride. * p < 0.05 versus control; # p < 0.05 versus 8-week CCl4