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Table 1 Variation of ultrasound and contrast-enhanced ultrasound parameters of ovaries in decapeptyl-treated mice versus controls

From: Contrast-enhanced ultrasound for ovary assessment in a murine model: preliminary findings on the protective role of a gonadotropin-releasing hormone analogue from chemotherapy-induced ovarian damage

  Day 0 Day 10 Day 20
Decapeptyl Controls p value Decapeptyl Controls p value Decapeptyl Controls p value
Ultrasound (B-mode)
 Ovary diameter (mm) 2.427 ± 0.70 2.039 ± 0.38 0.190 2.805 ± 0.66 2.260 ± 0.50 0.102 2.470 ± 0.77 2.183 ± 0.48 0.456
 Dominant follicle diameter (mm) 0.242 ± 0.07 0.183 ± 0.06 0.248 0.659 ± 0.07 0.170 ± 0.05 < 0.001 0.430 ± 0.13 0.235 ± 0.05 0.070
Contrast-enhanced ultrasound
 Peak enhancement (a.u.) 80.95 ± 6.86 41.8 ± 9.475 0.042 87.25 ± 0.21 88.60 ± 57.56 0.981 17.10 ± 18.67 145.0 ± 12.73 0.015
 Wash-in-rate (a.u.) 27.83 ± 15.84 29.67 ± 14.00 0.643 58.87 ± 48.04 66.25 ± 68.94 0.561 9.09 ± 10.35 98.65 ± 28.78 0.054
 Time to peak (s) 5.22 ± 2.02 4.07 ± 1.85 0.611 9.94 ± 8.10 4.04 ± 2.00 0.422 4.19 ± 0.67 3.04 ± 0.62 0.219
 Rise time (s) 4.27 ± 1.66 3.65 ± 1.58 0.739 9.125 ± 7.66 3.460 ± 1.39 0.412 3.45 ± 0.74 2.545 ± 0.49 0.284
 Area under the curve (a.u.) 3145.00 ± 657.61 2120.00 ± 735.39 0.279 5045.00 ± 2538.51 2450.00 ± 1088.94 0.315 362.50 ± 195.87 4975.00 ± 473.76 0.006
 Mean transit time (s) 41.76 ± 25.51 59.60 ± 17.34 0.499 76.13 ± 26.51 27.34 ± 0.23 0.121 42.79 ± 33.60 55.82 ± 14.40 0.664
 Perfusion index (a.u./s) 86.70 ± 37.19 35.30 ± 1.98 0.190 64.40 ± 10.89 89.35 ± 39.10 0.476 14.84 ± 16.21 91.20 ± 15.27 0.040
 Wash-in perfusion index (a.u./s) 54.60 ± 3.82 29.15 ± 7.00 0.457 62.80 ± 4.24 62.25 ± 43.06 0.987 11.35 ± 12.23 97.7 ± 8.91 0.015
 Wash-in area under the curve (a.u.) 230.00 ± 73.54 100.65 ± 20.29 0.139 589.50 ± 519.72 185.50 ± 62.93 0.389 34.65 ± 33.87 246.50 ± 24.75 0.019
  1. Data are presented as mean ± standard deviation
  2. a.u. arbitrary units