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European Radiology Experimental
Fig. 5 | European Radiology Experimental

Fig. 5

From: Noninvasive assessment and quantification of tumour vascularisation using MRI and CT in a tumour model with modifiable angiogenesis – An animal experimental prospective cohort study

Fig. 5

a. Details of xenograft tumours: T2-weighted images fused on corresponding colour-coded apparent diffusion coefficient (ADC) maps. Upper row: tumours from cell line A549; lower row: tumours from cell line H1299. Left column: non-co-transplanted tumours; right column: co-transplanted tumours. Left column: the image fusion of the ADCdiff maps of non-co-transplanted tumours reveals comparatively homogenous and intermediate values of diffusion (green). Right column: the image fusion of the ADCdiff maps of co-transplanted tumours reveals the existence of extreme values of diffusion (red = high; dark blue = low). Range of ADCdiff (mm2/s × 10−6) in the tumour were: top line left, 312–1593; top line right, 31–1586; lower line left, 55–1920; lower line right, 30–2584. b. Details of xenograft tumours: T2-weighted images fused on corresponding colour-coded ADC maps. Upper row: tumours from cell line A549; lower row: tumours from cell line H1299. Left column: non-co-transplanted tumours; right column: co-transplanted tumours. Left column: the image fusion of the ADCperf maps of non-co-transplanted tumours reveals only very few vessels that are large enough to be visualised (green dot). Right column: the image fusion of the ADCperf maps of co-transplanted tumours reveals larger perfused vessels (green linear structures). Range of ADCperf (mm2/s × 10−6) in the tumour were: top line left, 3–3502; top line right, 1–3977; lower line left, 1–2733; lower line right, 2–3920

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