28 days post-treatment | 56 days post-treatment | |||
---|---|---|---|---|
Group | GBCA | |||
Blood (nmol Gd/mL) | ||||
SN rats | 1 | Gadoteridol | 0.101 ± 0.53 | 0.0116 ± 0.0046a4 |
n | 7 | 8 | ||
2 | Gadobutrol | 0.099 ± 0.017c4 | 0.0167 ± 0.0086b4 | |
n | 8 | 7 | ||
3 | Gadoterate | 0.094 ± 0.026b4 | 0.0152 ± 0.072a4 | |
n | 9 | 8 | ||
Healthy rats | 4 | Gadoteridol | 0.045 ± 0.014c2,b3 | 0.004 ± 0.001a1,b2,a3 |
n | 5 | 4 | ||
Liver (nmol Gd/g) | ||||
SN rats | 1 | Gadoteridol | 2.2 ± 1.3a4 | 0.64 ± 0.28 |
n | 8 | 8 | ||
2 | Gadobutrol | 4.2 ± 1.8b4 | 1.39 ± 0.81a4 | |
n | 8 | 7 | ||
3 | Gadoterate | 3.9 ± 2.1b4 | 2.0 ± 1.1a4 | |
n | 9 | 7 | ||
Healthy rats | 4 | Gadoteridol | 0.295 ± 0.087a1,b2,b3 | 0.132 ± 0.031a2,a3 |
n | 5 | 5 | ||
Femur (nmol Gd/g) | ||||
SN rats | 1 | Gadoteridol | 17.1 ± 5.4b4 | 15.4 ± 3.7c4 |
n | 8 | 8 | ||
2 | Gadobutrol | 25.3 ± 9.5b4 | 24.9 ± 9.3b4 | |
n | 8 | 7 | ||
3 | Gadoterate | 20 ± 12a4 | 16 ± 10 | |
n | 9 | 8 | ||
Healthy rats | 4 | Gadoteridol | 6.6 ± 1.6b1,b2,a3 | 5.24 ± 0.19b2,c1 |
n | 5 | 5 | ||
Kidneys (nmol Gd/g) | ||||
SN rats | 1 | Gadoteridol | 206 ± 70c2,b3,c4 | 50 ± 36b2,a3,a4 |
n | 8 | 8 | ||
2 | Gadobutrol | 991 ± 153c1,c4 | 265 ± 82b1,b4 | |
n | 7 | 6 | ||
3 | Gadoterate | 1286 ± 269b1,c4 | 283 ± 144a1,a4 | |
n | 9 | 7 | ||
Healthy rats | 4 | Gadoteridol | 9.0 ± 3.2c1,c2,c3 | 4.0 ± 1.7a1,b2,a3 |
n | 4 | 5 | ||
Skin (nmol Gd/g) | ||||
SN rats | 1 | Gadoteridol | 1.32 ± 0.38c4 | 0.475 ± 0.092c4 |
n | 8 | 7 | ||
2 | Gadobutrol | 2.6 ± 1.6b4 | 0.71 ± 0.23a4 | |
n | 8 | 6 | ||
3 | Gadoterate | 2.0 ± 1.0a4 | 0.68 ± 0.43a4 | |
n | 7 | 8 | ||
Healthy rats | 4 | Gadoteridol | 0.42 ± 0.15c1,b2.a3 | 0.188 ± 0.005c1, a2, a3 |
n | 4 | 4 |