European Radiology Experimental

Table 1 Gadolinium content in the nervous system

From: Gadolinium retention in a rat model of subtotal renal failure: are there differences among macrocyclic GBCAs?

			28 days post-treatment	56 days post-treatment
	Group	GBCA
Cerebrum (nmol Gd/g)
SN rats	1	Gadoteridol	0.304 ± 0.088^b2,c3,c4	0.132 ± 0.022^b2,c3,c4
	n		8	8
	2	Gadobutrol	0.57 ± 0.12^b1,c4	0.348 ± 0.097^b1,c4
	n		8	7
	3	Gadoterate	0.554 ± 0.074^c1,c4	0.321 ± 0.064^c1,c4
	n		8	7
Healthy rats	4	Gadoteridol	0.087 ± 0.015^c1,c2,c3	0.053 ± 0.007^c1,c2,c3
Healthy rats	n		5	5
Cerebellum (nmol Gd/g)
SN rats	1	Gadoteridol	0.328 ± 0.081^b2,b3	0.264 ± 0.094^b4
	n		8	8
	2	Gadobutrol	0.66 ± 0.23^b1,c4	0.36 ± 0.10^b4
	n		8	7
	3	Gadoterate	0.63 ± 0.13^b1,c4	0.278 ± 0.036^c4
	n		8	7
Healthy rats	4	Gadoteridol	0.16 ± 0.1^c2,c3	0.084 ± 0.022^b1,b2,c3
Healthy rats	n		5	5
Peripheral nerves (nmol Gd/g)
SN rats	1	Gadoteridol	0.60 ± 0.29^c2,c3,a4	0.166 ± 0.23^a3
	n		8	7
	2	Gadobutrol	3.24 ± 0.81^c1,c4	0.45 ± 0.22
	n		7	6
	3	Gadoterate	4.3 ± 1.4^c1,c4	0.78 ± 0.58^a1,c4
	n		8	8
Healthy rats	4	Gadoteridol	0.197 ± 0.035^a1,c2,c3	0.114 ± 0.028^c3
Healthy rats	n		5	5

Values presented as mean ± SD
^ap < 0.05; ^bp < 0.01; ^cp < 0.001. The number after the letter of the significance level indicates the group versus which there is a difference. See main text for actual p values

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