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Fig. 7 | European Radiology Experimental

Fig. 7

From: Variability of noninvasive MRI and biological markers in compensated cirrhosis: insights for assessing disease progression

Fig. 7

A schematic of the hazard ratio (HR) for disease progression. Panel a (i) shows the progression from healthy volunteer (HV) to compensated cirrhosis (CC), whilst panel a (ii) shows that the hazard ratio for progression from CC to decompensated cirrhosis (DC). Positive values indicate an increase in measure and negative values a decrease in measures. If the absolute value of the HR is >1 this indicates the reference change value (RCV) is less than the clinical change. Panel b shows sample size estimation for the number of CC patients required in clinical trial to detect a change from stage F4 (compensated cirrhosis, CC) to F3 (advanced cirrhosis) liver disease which has clinical significance; data points are shown for a 25%, 50%, 75%, and 100% regression from F4 to F3. BSA Body surface area

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