Radiologic-pathologic correlation in breast cancer: do MRI biomarkers correlate with pathologic features and molecular subtypes?

European Radiology Experimental

Table 1 Association between histological subtypes of breast cancer

		DCIS	χ2 analysis p-value	Invasive carcinoma no special type	χ2 analysis p-value	ILC	χ2 analysis p-value
No. of patients		15		122		19
Tumour size	Median (mm) Range (mm)	38 7–72		20 6–90		26 8–100
≥ 2 cm		10/15	0.429	65/122	0.071	14/19	0.118
T2 intensity	Hypointensity Isointensity Hyperintensity	0/15 12/15 3/15	< 0.001	55/122 30/122 37/122	0.015^a	9/19 5/19 5/19	0.833
Mass enhancement		2/15	< 0.001	102/122	< 0.001	12/19	0.233
Rim enhancement		0/2	0.292	39/102	0.079	2/12	0.153
Intralesional necrosis		0/15	0.001	53/122	0.035	8/19	0.775
Perilesional oedema		6/15	0.358	67/122	0.085	7/19	0.179
Axillary adenopathy		0/15	0.003	48/122	0.007	5/19	0.452
Intensity-to-time curve	Type I Type II Type III	1/15 5/15 9/15	0.801	10/122 31/122 81/122	0.877	2/19 5/19 12/19	0.932
ADC value	Very low Low Intermediate	3/10 6/10 1/10	0.055	70/111 39/111 2/111	0.144	7/14 7/14 0/14	0.575
Extent of disease	Unifocal Multifocal Multicentric	7/15 0/15 8/15	0.018 ^a	55/122 39/122 28/122	0.02	9/19 2/19 8/19	0.170

^aBonferroni’s post hoc analysis found no significance. ADC Apparent diffusion coefficient, DCIS Ductal carcinoma in situ, ILC Invasive lobular carcinoma