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Table 3 Correlation between clinical profile and brain iron concentrations (global and regional) in MS patients

From: Iron deposition in multiple sclerosis: overall load or distribution alteration?

  Global iron load
(Iron load per cc2 brain volume)
Regional iron load (n = 500 ROIs)
Basal ganglia Thalami NAWM MS periventricular lesions
Age p > 0.05 p > 0.05 p > 0.05 p > 0.05 r = – 0.163, p = 0.023*
Disease duration p > 0.05 p > 0.05 p > 0.05 r = – 0.323, p = 0.012* r = – 0.292, p < 0.001*
Number of relapses p > 0.05 p > 0.05 p > 0.05 p > 0.05 p > 0.05
INF-β durationa p > 0.05 p > 0.05 p >0.05 p > 0.05 r = 0.165, p = 0.021*
EDSS p > 0.05 r = 0.200, p = 0.029* p > 0.05 p > 0.05 r = – 0.167, p = 0.019*
T25FW p > 0.05 p > 0.05 r = -0.285, p = 0.027* r = – 0.268, p = 0.039* r = – 0.240, p = 0.001*
SDMT p > 0.05 p > 0.05 p > 0.05 p > 0.05 p > 0.05
  1. EDSS Expanded disability status scale, INF-β Interferon beta therapy, MS Multiple sclerosis, n Number, NAWM Normal-appearing white matter, r Spearman coefficient, ROIs Regions of interest, T25FW Timed 25-foot walking test, SDMT Symbol digit modality test
  2. aEvaluated in the patients who received treatment only
  3. *Statistically significant