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Table 2 Brain global and regional iron concentrations in the studied sample

From: Iron deposition in multiple sclerosis: overall load or distribution alteration?

  MS patients (n= 500 ROIs) HC
(n= 500 ROIs)
P0 P1 P2 P3
Total Benign Aggressive Naive
Brain volume in cm3 a 1,903 1,909 1,887 1,911 2,075 0.047* 0.924 0.995 0.789
Global iron load in ppb, medianb -4.2808 -4.1009 -4.6923 -4.1983 -2.9640 0.647 0.450 0.940 0.545
Iron load ppb in cm3b -20.994 -0.7859 -32.011 -28.164 -14.577 0.660 0.227 0.247 0.661
Regional iron load in ppbb
 – Basal ganglia 0.011 0.009 0.013 0.009 0.008 0.442 0.042* 0.439 0.392
 – Thalami -0.002 -0.002 -0.003 -0.001 -0.001 0.550 0.552 0.552 0.989
 – NAWM -0.007 -0.005 -0.009 -0.007 -0.012 0.031* 0.291 0.414 0.787
 – MS lesions -0.029 -0.004 -0.003 -0.041 0.004 < 0.001* 0.225 0.037* 0.249
  – Periventricular -0.027 0.009 -0.010 -0.044 0.009 0.001* 0.301 0.004* 0.061
  – Juxtacortical -0.033 -0.063 -0.012 -0.043 0.013 0.017* 0.576 0.945 0.475
  – Infratentorial -0.059 -0.070 -0.097 -0.016 -0.035 0.419 0.440 0.465 0.083
P4 <0.001* 0.025* 0.001* < 0.001* <0.001*  
P5 0.070 0.147 0.032* 0.417 0.169
  1. cm3 Cubic centimeter, HC Healthy controls, n Number, NAWM Normal-appearing white matter, P0 Difference between patients and controls, P1 Difference between benign and aggressive MS, P2 Difference between benign and drug naïve patients, p3 Difference between aggressive and naïve patients, p4 Differences between iron load in all locations within the same group, p5 Differences between iron load between MS lesions (or corresponding locations in healthy controls) within the same group, ppb Parts per billion
  2. aMean
  3. bmedian
  4. *Statistically significant