From: Iron deposition in multiple sclerosis: overall load or distribution alteration?
 | MS patients (n = 30) | HC (n = 15) | P1 | P2 | |||
---|---|---|---|---|---|---|---|
Total | Benign (n = 10) | Aggressive (n = 10) | Naïve (n = 10) | ||||
Age in yearsa | 34.5 ± 7.51 | 30.2 ± 5.63 | 37.3 ± .74 | 36.3 ± 10.09 | 36.27 ± 10.27 | 0.512 | 0.075 |
Gender, n (%) | |||||||
 – Male | 7 (23.3) | 2 (20) | 2 (20) | 3 (30) | 4 (26.7) | 0.540 | 0.830 |
 – Female | 23 (76.7) | 8 (80) | 8 (80) | 7 (70) | 11 (73.3) |  |  |
Disease durationb | 7.0 (6–7.25) | 6 (5–7.25) | 6.50 (5.75–7.25) | 7 (6–9) | – | – | 0.379 |
DMT durationb | 2 (0–3) | 2.5 (1.75–3.5) | 3 (2.75–4.25) | – |  |  | < 0.001* |
EDSSb | 3.5 (2.5–4.13) | 2 (2–2) | 4 (4–5.87) | 3.5 (2.4–6.0) | – | – | 0.001* |
Total number of relapsesb | 5.0 (4.0–7.0) | 4 (3.75–6.25) | 7 (6–11.25) | 4.5 (2.75–6) | – | – | 0.041* |
SDMTa | 33.30 ± 14.99 | 39.8 ± 13.06 | 27.1 ± 12.21 | 3.0 ± 17.76 | – | – | 0.168 |
9-HPTb | |||||||
 – Right hand | 23.86 (22.03–31.45) | 21.6 (19.4–23.2) | 28.1 (23.8–43.1) | 24.1 (22.2–34.1) | – | – | 0.011* |
 – Left hand | 28.11 (24.52–37.63) | 25.1 (23.0–27.3) | 30.9 (26.3–46.6) | 30.8 (26.5–39.1) | – |  | 0.052 |
T25FW testb | 8.84 (7.09-12.82) | 6.9 (6.5–8.3) | 12.5 (8.6–17.4) | 11.1 (7.4–16.6) | – | – | 0.009* |