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Table 1 Sample descriptive analysis (n = 45)

From: Iron deposition in multiple sclerosis: overall load or distribution alteration?

 

MS patients (n = 30)

HC

(n = 15)

P1

P2

Total

Benign (n = 10)

Aggressive (n = 10)

Naïve (n = 10)

Age in yearsa

34.5 ± 7.51

30.2 ± 5.63

37.3 ± .74

36.3 ± 10.09

36.27 ± 10.27

0.512

0.075

Gender, n (%)

 – Male

7 (23.3)

2 (20)

2 (20)

3 (30)

4 (26.7)

0.540

0.830

 – Female

23 (76.7)

8 (80)

8 (80)

7 (70)

11 (73.3)

  

Disease durationb

7.0 (6–7.25)

6 (5–7.25)

6.50 (5.75–7.25)

7 (6–9)

0.379

DMT durationb

2 (0–3)

2.5 (1.75–3.5)

3 (2.75–4.25)

  

< 0.001*

EDSSb

3.5 (2.5–4.13)

2 (2–2)

4 (4–5.87)

3.5 (2.4–6.0)

0.001*

Total number of relapsesb

5.0 (4.0–7.0)

4 (3.75–6.25)

7 (6–11.25)

4.5 (2.75–6)

0.041*

SDMTa

33.30 ± 14.99

39.8 ± 13.06

27.1 ± 12.21

3.0 ± 17.76

0.168

9-HPTb

 – Right hand

23.86 (22.03–31.45)

21.6 (19.4–23.2)

28.1 (23.8–43.1)

24.1 (22.2–34.1)

0.011*

 – Left hand

28.11 (24.52–37.63)

25.1 (23.0–27.3)

30.9 (26.3–46.6)

30.8 (26.5–39.1)

 

0.052

T25FW testb

8.84 (7.09-12.82)

6.9 (6.5–8.3)

12.5 (8.6–17.4)

11.1 (7.4–16.6)

0.009*

  1. 9-HPT Nine hole-peg hole test, DMT Disease-modifying therapy, EDSS Expanded disability status scale, HC Healthy controls, MS Multiple sclerosis, n Number, SDMT Symbol digit modality test, T25FW Timed 25-foot walking, p1: Difference between the patients and HC, p2: Difference between subgroups of patients
  2. aMedian ± SD
  3. bMedian (IQR)
  4. *Statistically significant