Fig. 3
From: Iron deposition in multiple sclerosis: overall load or distribution alteration?
Measurement of regional iron in a 25-year-old man with MS. Images Ia, Ib, and Ic represent the steps of measuring iron concentrations in the normal appearing white matter (region of interest [ROI] 1) and multiple sclerosis lesions (ROI 2). Ia is an axial three-dimensional fluid-attenuation inversion recovery (3D FLAIR) film demonstrating the MS lesions. Ib is the 3D FLAIR image overlayed onto the quantitative susceptibility mapping, and Ic is the quantitative susceptibility map. Similar steps are demonstrated in IIa, IIb, and IIc to measure iron concentrations in the deep grey matter: caudate (ROIs 3 and 4), putamen (ROIs 5 and 6), globus pallidus (ROIs 7 and 8), and thalami (ROIs 9 and 10).