Table 2 Required data for sample size calculations
Model | Prevalence | Median tevent | tfollow-up | Rate | Time point | Follow-up |
|---|---|---|---|---|---|---|
NB 5-year mortality risk | 0.307 | – | – | – | – | – |
NB relapse/progression risk | 0.258 | – | – | – | – | – |
NB time to death | 0.307 | 24.2 | 60 | 0.0063 | 24 | 24 |
HR-NB 5-year mortality risk | 0.500 | – | – | – | – | – |
HR-NB 5-year relapse/progression risk | 0.408 | - | – | – | – | – |
HR-NB time to relapse/progression | 0.561 | 19.08 | 72.12 | 0.0132 | 24 | 24 |
DIPG 1-year mortality risk | 0.450 | – | – | – | – | – |
DIPG 2-year mortality risk | 0.169 | – | – | – | – | – |
DIPG 1-year progression risk | 0.235 | – | – | – | – | – |
DIPG time to death | 0.169 | 11.4 | 24 | 0.0077 | 24 | 24 |
DIPG time to progression | 0.235 | 7.7 | 12 | 0.0214 | 12 | 12 |