Reproducibility of radiomic features in CT images of NSCLC patients: an integrative analysis on the impact of acquisition and reconstruction parameters

European Radiology Experimental

Table 1 Baseline characteristics of the study population.

Variables	Overall cohort (n = 103)	Scanner Optima CT660 (n = 50)	Scanner DiscoveryCT750 HD (n = 53)	p value (scanner)	Tube voltage 120 kVp (n = 51)	Tube voltage 100 kVp (n = 52)	p value (kVp)
Gender
Male Female	59 (57%) 44 (43%)	28 (56%) 22 (44%)	31 (58%) 22 (42%)	0.798^a	33 (65%) 18 (35%)	26 (50%) 26 (50%)	0.131^a
Age
Mean (median) IQR	69.2 (70) (64–75)	69.4 (70) (65–75.3)	68.9 (69) (62–74.5)	0.498^c	69.8 (70) (64–76)	68.6 (68.5) (62–74.8)	0.251^c
Side Right Left	60 (58%) 43 (42%)	31 (62%) 19 (38%)	29 (55%) 24 (45%)	0.454^a	31 (61%) 20 (39%)	29 (56%) 23 (44%)	0.606^a
Position Upper Medium Lower Mixed	63 (64%) 1 (1%) 29 (30%) 5 (5%)	33 (69%) 1 (2%) 13 (27%) 1 (2%)	30 (60%) 0 (0%) 16 (32%) 4 (8%)	0.360^b	30 (61%) 1 (2%) 16 (33%) 2 (4%)	33 (67%) 0 (0%) 13 (27%) 3 (6%)	0.731^b
Volume (cm³)
Mean (median) IQR	46.4 (39.1) (19.1–62.8)	44.2 (40.6) (19–54.7)	48.5 (38.1) (19.5–71.9)	0.843^c	52.1 (42) (20.7–67.9)	40.9 (36.7) (18.4–56.2)	0.181^c
Histological type
Adenocarcinoma Squamous cell carcinoma Neuroendocrine	83 (82%) 16 (16%) 2 (2%)	38 (78%) 10 (20%) 1 (2%)	45 (87%) 6 (11%) 1 (2%)	0.580^b	40 (78%) 9 (18%) 2 (4%)	43 (86%) 7 (14%) 0 (0%)	0.380^b
Previous therapy
No Yes	75 (74%) 26 (26%)	38 (76%) 12 (24%)	37 (73%) 14 (27%)	0.692^a	33 (66%) 17 (34%)	42 (82%) 9 (18%)	0.060^a
Scanner
Optima CT660 Discovery CT750 HD	50 (49%) 53 (51%)	–	–	–	25 (49%) 26 (51%)	25 (48%) 27 (52%)	0.924^a
Tube voltage (kVp)
120 100	51 (50%) 52 (50%)	25 (50%) 25 (50%)	26 (49%) 27 (51%)	0.924^a	–	–	–

^aχ² test
^bFisher’s exact test
^cWilcoxon-Mann-Whitney test. Missing data: histological type (n = 2); previous therapy (n = 2); position (n = 5). IQR Interquartile range