Fig. 10
41-year-old man with glioblastoma in the left frontal lobe. Conventional T1-weighted spin-echo contrast-enhanced images for the first exam with gadobutrol (a) and the second exam with gadoteridol (b) and the QE change map (c) where colour indicates regions differing in enhancement between the two exams. Scatter charts (T1-weighted contrast-enhanced versus unenhanced) of enhancing voxel ROIs reveals the patterns of enhancement for gadobutrol (d) and gadoteridol (e). The volume of interest was 12.342 cm3 and 11,140 voxels were measured. The net QE was + 2,102.98 for gadobutrol and + 2,119.53 for gadoteridol. The gadoteridol minus gadobutrol difference (16.55, 0.79%) was not significant and the 90% confidence interval for the mean of the differences fell entirely within the equivalence zone (f), indicating equivalence for the two contrast agents