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European Radiology Experimental
Fig. 1 | European Radiology Experimental

Fig. 1

From: The TRUTH confirmed: validation of an intraindividual comparison of gadobutrol and gadoteridol for imaging of glioblastoma using quantitative enhancement analysis

Fig. 1

The quantitative enhancement (QE) analysis pipeline for comparing two GBCAs. T1-weighted unenhanced/T1-weighted contrast-enhanced pairs are acquired for both contrast agents. Bias field correction using the N4 algorithm is performed on all images, after which images are registered using an “all to one” approach. Subsequently, machine learning based intensity harmonisation is performed “all to one”. QE maps are calculated for each GBCA, and the difference between the QE map for the two GBCAs is calculated

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