Table 2 Bopta and Meb accumulation and decay parameters in livers and hepatocytes

Livers

Normal

Normal

no Mrp2

T_0,liver [min]

8.0 ± 0.5

5.5 ± 1.1

< 0.001

-

T_0,HC [min]

4.7 ± 1.3

4.0 ± 1.5

.37

-

_SlopeL_1,liver [μM/min]

37 ± 5

333 ± 71

< 0.001

28 ± 6*

_SlopeL_1,HC [μM/min]

57 ± 16

452 ± 107

< 0.001

35 ± 8**

_SlopeL_2,liver [μM/min]

8 ± 1

16 ± 5

< 0.001

-

_SlopeL_2,HC [μM/min]

8 ± 2

22 ± 7

< 0.001

-

k_el,liver [min⁻¹]

0.09 ± 0.01

0.13 ± 0.02

< 0.001

-

k_el,HC [min⁻¹]

0.10 ± 0.02

0.16 ± 0.03

< 0.001

-

T_1/2,liver [min]

7.6 ± 0.9

5.5 ± 0.7

< 0.001

-

T_1/2,HC [min]

7.4 ± 1.3

4.5 ± 0.6

< 0.001

-

CL_el,HC [mL/min]

0.95 ± 0.17

1.44 ± 0.26

< 0.001

-