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Table 4 Virtual non-calcium computed tomography ability to depict traumatic bone marrow edema on dual-energy scans of appendicular skeleton

From: Virtual non-calcium dual-energy CT: clinical applications

Author

DECT platform

Number of patients

Qualitative analysis (sensitivity, specificity, accuracy)

Quantitative analysis cutoff (sensitivity, specificity, accuracy)

Reference standard

Anatomical site

Yang et al., 2020 [81]

DSCT

156

92%, 93%, 93%

NA

MRI

Knee

Booz et al., 2020 [82]

DSCT

56

96%, 97%, 97%

-51 HU* (96%, 97%, 96%)

MRI

Knee

Yadav et al., 2020 [83]

DSCT

40

94%, 91%, 92%

NA

MRI

Lower limb

Wang et al, 2019 [80]

DSCT

35

88%, 98%, 95%

-67 HU (81%, 99%, 90%)

MRI

Knee

Booz et al., 2019 [85]

DSCT

62

92%, 97%, 98%

-53 HU (82%, 95%, 98%)

MRI

Calcaneus

Foti et al., 2019 [87]

DSCT

40

92%, 86%, 90%

-20 HU (88%, 92%, 87%)

MRI

Ankle

Jang et al., 2019 [36]

DSCT

35

100%, 100%, 100%

-55 HU (100%, 94%, 95%)

Standard CT

Hip

Ali et al., 2018 [86]

DSCT

24

NA

6 HU (100%, 99%, 100%)

Visual assessment

Wrist

Kellock et al., 2017 [37]

DSCT

118

100%, 100%, NA

NA

Clinical follow-up

Hip

Reddy et al., 2015 [69]

DSCT

25

90%, 40%, NA

NA

Clinical follow-up

Hip

Guggenberger et al., 2012 [47]

DSCT

30

90%, 81%, 97%

NA

MRI

Ankle

  1. BME Bone marrow edema, CT Computed tomography, DECT Dual-energy computed tomography, DSCT Dual-source computed tomography, HU Hounsfield units; NA Not available, MRI Magnetic resonance imaging. *Cutoff value refers to tibial BME