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Table 2 Characteristics of patients with CT diagnosis of liver nodules and histopathology correlation

From: Material decomposition using iodine quantification on spectral CT for characterising nodules in the cirrhotic liver: a retrospective study

Characteristics Total nodules
330
HCC on CT 133
(40.3%)
Indeterminate on CT
50
(15.2%)
Regenerative on CT
147
(44.5%)
p-value
Age (years, mean ± SD) 53.2 ± 12.7 58.6 ± 11.6 56.7 ± 10 47.1 ± 11.8 < 0.001
Gender (male/female) 266/64 108/25 38/12 120/27 0.667
Log AFP (ng/mL, mean ± SD) 2.63 ± 3.1 3.5 ± 2.3 3.01 ± 2.4 1.7 ± 1.1 < 0.001
Nodule size (cm, median (IQR)) 1.7 (1.1–2.1) 2.1 (1.9–5.0) 1.4 (1.2–1.6) 1.2 (1–1.8) < 0.001
Increased AFP (> 8.5 ng/mL) (%) 138 (41.8) 84 (63.1) 31 (62) 23 (15.6) < 0.001
Nodules classified according to size (largest diameter) on CT
 < 1 cm (% of total nodules) 29 (8.8) 0 (0) 2 (4) 27 (18.5) < 0.001
 1–2 cm (% of total nodules ) 198 (60) 48 (36) 44 (88) 106 (72)
 > 2 cm (% of total nodules) 103 (31.2) 85 (63.9) 4 (8) 14 (9.5)
CT histopathology correlation
Histopathology classification (%) HCC
136 (41.2%)
Dysplastic
11 (3.3%)
Regenerative
183 (55.5%)
True positive on CT 129 7 141
True negatives on CT 190 276 141
False positive on CT 4 43 6
False negative on CT 7 4 42
Sensitivity % (95% CI) 94.9 (89.8–97.5) 63.6 (35.4–84.8) 77.0 (70.4–82.5)
Specificity % (95% CI) 97.9 (94.8–99.2) 86.5 (82.3–89.8) 95.9 (91.4–98.1)
PPV % (95% CI) 96.9 (92.5–98.8) 14 (6.9–6.2) 95.9 (91.4–98.1)
NPV % (95% CI) 96.5 (92.9–98.3) 98.6 (96.4–99.44) 77.1 (70.4–82.5)
Accuracy % (95% CI) 96.7 (94.1–98.1) 85.8 (81.6–89.1) 85.5 (81.2–88.9)
  1. AFP Alpha-fetoprotein, CT Computed tomography, CI Confidence interval, IQR Interquartile range, SD Standard deviation, NPV Negative predictive value, PPV Positive predictive value