Breast cancer: comparison of quantitative dual-layer spectral CT and axillary ultrasonography for preoperative diagnosis of metastatic axillary lymph nodes

European Radiology Experimental

Table 4 Diagnostic performance for axillary ultrasonography and quantitative dual-layer spectral CT parameters for differentiating metastatic and non-metastatic axillary lymph nodes

	Cutoff	AUC	Sensitivity	Specificity	PPV	NPV
Axillary ultrasound		0.88	0.75	1.00	1.00	0.67
Iodine density (mg/mL)	1.5	0.80	0.79	0.73	0.83	0.62
Spectral slope	0.82	0.83	0.79	0.83	0.90	0.63
Z effective	183	0.83	0.79	0.83	0.90	0.67
Conventional CT HU	53	0.79	0.58	0.92	0.93	0.52
VNC (HU)	18	0.78	0.79	0.67	0.83	0.62
Δ contrast enhancement (HU)	17	0.87	0.79	0.92	0.95	0.69

CT Computed tomography, VNC Virtual non-contrast. AUC Area under the curve, NPV Negative predictive value, PPV Positive predictive value