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European Radiology Experimental
Fig. 2 | European Radiology Experimental

Fig. 2

From: A novel roadmap connecting the 1H-MRS total choline resonance to all hallmarks of cancer following targeted therapy

Fig. 2

ER elongation after UPR induced stress. a Determination of ER elongation in cells before (control) and after UPR stress (UPR-induced). TEM examinations of thin sections of a control and an UPR-induced cell were magnified to a resolution of 140 nm (upper images) in which the cortical ER was outlined in magenta, and the nuclear envelope outlined in blue (lower images). Cursory glance reveals UPR stress causes ER elongation with inward displacement of the ER away from the plasma membrane. b Quantification of the cortical ER and nuclear envelope after UPR induction. Length of the ER (as traced in a) was measured and divided by area of the section generating a normalised length (a.u.). Data plotted relative to time 0. Measurement for each time point corresponds to mean of 25 independent cells. ER, Endoplasmic reticulum; TEM, Transmission electron microscopy; UPR, Unfolded protein response. Adapted with permission from Bernales et al. [10]

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