TY - STD TI - Sharpe AH, Pauken KE (2018) The diverse functions of the PD1 inhibitory pathway. Nat Rev Immunol 18:153–167. https://doi.org/10.1038/nri.2017.108 ID - ref1 ER - TY - STD TI - Wang Z, Cao YJ (2020) Adoptive cell therapy targeting neoantigens: a frontier for cancer research. Front Immunol 11:176. https://dx.doi.org/10.3389%2Ffimmu.2020.00176 UR - https://dx.doi.org/10.3389%2Ffimmu.2020.00176 ID - ref2 ER - TY - STD TI - Weber EW, Maus MV, Mackall CL (2020) The emerging landscape of immune cell therapies. Cell 181:46–62. https://doi.org/10.1016/j.cell.2020.03.001 ID - ref3 ER - TY - STD TI - Champiat S, Ferrara R, Massard C et al (2018) Hyperprogressive disease: recognizing a novel pattern to improve patient management. Nat Rev Clin Oncol 15:748–762. https://doi.org/10.1038/s41571-018-0111-2 ID - ref4 ER - TY - STD TI - Friedman CF, Proverbs-Singh TA, Postow MA (2016) Treatment of the immune-related adverse effects of immune checkpoint inhibitors: a review. JAMA Oncol 2:1346–1353. https://doi.org/10.1001/jamaoncol.2016.1051 ID - ref5 ER - TY - STD TI - Delbeke D, Schöder H, Martin WH, Wahl RL (2009) Hybrid imaging (SPECT/CT and PET/CT): improving therapeutic decisions. Semin Nucl Med 39:308–340. https://doi.org/10.1053/j.semnuclmed.2009.03.002 ID - ref6 ER - TY - STD TI - Eichenauer DA, Aleman BMP, André M et al (2018) Hodgkin lymphoma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 29:iv19–iv29. https://doi.org/10.1093/annonc/mdy080 ID - ref7 ER - TY - STD TI - Buckner CD, Epstein RB, Rudolph RH, Clift RA, Storb R, Thomas ED (1970) Allogeneic marrow engraftment following whole body irradiation in a patient with leukemia. Blood 35:741–750 ID - ref8 ER - TY - STD TI - Wang W, Erbe AK, Hank JA, Morris ZS, Sondel PM (2015) NK cell-mediated antibody-dependent cellular cytotoxicity in cancer immunotherapy. Front Immunol 6:368. https://doi.org/10.3389/fimmu.2015.00368 ID - ref9 ER - TY - STD TI - Gul N, Babes L, Siegmund K et al (2014) Macrophages eliminate circulating tumour cells after monoclonal antibody therapy. J Clin Invest 124:812–823. https://doi.org/10.1172/jci66776 ID - ref10 ER - TY - STD TI - Montalvao F, Garcia Z, Celli S et al (2013) The mechanism of anti-CD20-mediated B cell depletion revealed by intravital imaging. J Clin Invest 123:5098–5103. https://doi.org/10.1172/jci70972 ID - ref11 ER - TY - STD TI - Rogers LM, Veeramani S, Weiner GJ (2014) Complement in monoclonal antibody therapy of cancer. Immunol Res 59:203–210. https://doi.org/10.1007/s12026-014-8542-z ID - ref12 ER - TY - STD TI - Chambers CA, Kuhns MS, Egen JG, Allison JP (2001) CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumour immunotherapy. Annu Rev Immunol 19:565–594. https://doi.org/10.1146/annurev.immunol.19.1.565 ID - ref13 ER - TY - STD TI - Franquiz MJ, Short NJ (2020) Blinatumomab for the treatment of adult B-cell acute lymphoblastic leukemia: toward a new era of targeted immunotherapy. Biologics 14:23–34. https://doi.org/10.2147/btt.s202746 ID - ref14 ER - TY - STD TI - Loffler A, Gruen M, Wuchter C et al (2003) Efficient elimination of chronic lymphocytic leukaemia B cells by autologous T cells with a bispecific anti-CD19/anti-CD3 single-chain antibody construct. Leukemia 17:900–909. https://doi.org/10.1038/sj.leu.2402890 ID - ref15 ER - TY - STD TI - Frigault MJ, Maus MV (2020) State of the art in CAR T cell therapy for CD19+ B cell malignancies. J Clin Invest 130:1586–1594. https://doi.org/10.1172/jci129208 ID - ref16 ER - TY - STD TI - Schuster SJ, Bishop MR, Tam CS et al (2019) Tisagenlecleucel in adult relapsed or refractory diffuse large B-cell lymphoma. N Engl J Med 380:45–56. https://doi.org/10.1056/nejmoa1804980 ID - ref17 ER - TY - STD TI - Neelapu SS, Locke FL, Bartlett NL et al (2017) Axicabtagene ciloleucel CAR T-cell therapy in refractory large B-cell lymphoma. N Engl J Med 377:2531–2544. https://doi.org/10.1056/nejmoa1707447 ID - ref18 ER - TY - STD TI - Abbasi A, Peeke S, Shah N et al (2020) Axicabtagene ciloleucel CD19 CAR-T cell therapy results in high rates of systemic and neurologic remissions in ten patients with refractory large B cell lymphoma including two with HIV and viral hepatitis. J Hematol Oncol 13:1. https://doi.org/10.1186/s13045-019-0838-y ID - ref19 ER - TY - STD TI - Eisenhauer EA, Therasse P, Bogaerts J et al (2009) New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer 45:228–247. https://doi.org/10.1016/j.ejca.2008.10.026 ID - ref20 ER - TY - STD TI - Wolchok JD, Hoos A, O'Day S et al (2009) Guidelines for the evaluation of immune therapy activity in solid tumours: immune-related response criteria. Clin Cancer Res 15:7412–7420. https://doi.org/10.1158/1078-0432.ccr-09-1624 ID - ref21 ER - TY - STD TI - Bohnsack O, Hoos A, Ludajic K (2014) Adaptation of the immune related response criteria: irRECIST. Ann Oncol 25:iv369. https://doi.org/10.1093/annonc/mdu342.23 ID - ref22 ER - TY - STD TI - Seymour L, Bogaerts J, Perrone A et al (2017) iRECIST: guidelines for response criteria for use in trials testing immunotherapeutics. Lancet Oncol 18:e143–e152. https://doi.org/10.1016/s1470-2045(17)30074-8 ID - ref23 ER - TY - STD TI - Therasse P, Arbuck SG, Eisenhauer EA et al (2000) New guidelines to evaluate the response to treatment in solid tumours. European Organization for Research and Treatment of cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 92:205–216. https://doi.org/10.1093/jnci/92.3.205 ID - ref24 ER - TY - STD TI - Schwartz LH, Litière S, de Vries E et al (2016) RECIST 1.1-update and clarification: from the RECIST committee. Eur J Cancer 62:132–137. https://doi.org/10.1016/j.ejca.2016.03.081 ID - ref25 ER - TY - STD TI - Chiou VL, Burotto M (2015) Pseudoprogression and immune-related response in solid tumours. J Clin Oncol 33:3541–3543. https://doi.org/10.1200/jco.2015.61.6870 ID - ref26 ER - TY - STD TI - Weber JS, D'Angelo SP, Minor D et al (2015) Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial. Lancet Oncol 16:375–384. https://doi.org/10.1016/s1470-2045(15)70076-8 ID - ref27 ER - TY - STD TI - Champiat S, Dercle L, Ammari S et al (2017) Hyperprogressive disease is a new pattern of progression in cancer patients treated by anti-PD-1/PD-L1. Clin Cancer Res 23:1920–1928. https://doi.org/10.1158/1078-0432.ccr-16-1741 ID - ref28 ER - TY - STD TI - Saâda-Bouzid E, Defaucheux C, Karabajakian A et al (2017) Hyperprogression during anti-PD-1/PD-L1 therapy in patients with recurrent and/or metastatic head and neck squamous cell carcinoma. Ann Oncol 28:1605–1611. https://doi.org/10.1093/annonc/mdx178v ID - ref29 ER - TY - STD TI - Frelaut M, Le Tourneau C, Borcoman E (2019) Hyperprogression under immunotherapy. Int J Mol Sci 20:2674. https://doi.org/10.3390/ijms20112674 ID - ref30 ER - TY - STD TI - Young H, Baum R, Cremerius U et al (1999) Measurement of clinical and subclinical tumour response using [18F]-fluorodeoxyglucose and positron emission tomography: review and 1999 EORTC recommendations. Eur J Cancer 35:1773–1782. https://doi.org/10.1016/s0959-8049(99)00229-4 ID - ref31 ER - TY - STD TI - Sachpekidis C, Larribere L, Pan L, Haberkorn U, Dimitrakopoulou-Strauss A, Hassel JC (2015) Predictive value of early 18 F-FDG PET/CT studies for treatment response evaluation to ipilimumab in metastatic melanoma: preliminary results of an ongoing study. Eur J Nucl Med Mol Imaging 42:386–396. https://doi.org/10.1007/s00259-014-2944-y ID - ref32 ER - TY - STD TI - Wahl RL, Jacene H, Kasamon Y, Lodge MA (2009) From RECIST to PERCIST: evolving considerations for PET response criteria in solid tumours. J Nucl Med 50:122S–150S. https://doi.org/10.2967/jnumed.108.057307 ID - ref33 ER - TY - STD TI - Cho SY, Lipson EJ, Im H-J et al (2017) Prediction of response to immune checkpoint inhibitor therapy using early-time-point 18F-FDG PET/CT imaging in patients with advanced melanoma. J Nucl Med 58:1421–1428. https://doi.org/10.2967/jnumed.116.188839 ID - ref34 ER - TY - STD TI - Anwar H, Sachpekidis C, Winkler J et al (2018) Absolute number of new lesions on 18 F-FDG PET/CT is more predictive of clinical response than SUV changes in metastatic melanoma patients receiving ipilimumab. Eur J Nucl Med Mol Imaging 45:376–383. https://doi.org/10.1007/s00259-017-3870-6 ID - ref35 ER - TY - STD TI - Sachpekidis C, Anwar H, Winkler J et al (2018) The role of interim 18 F-FDG PET/CT in prediction of response to ipilimumab treatment in metastatic melanoma. Eur J Nucl Med Mol Imaging 45:1289–1296. https://doi.org/10.1007/s00259-018-3972-9 ID - ref36 ER - TY - STD TI - Cheson BD, Horning SJ, Coiffier B et al (1999) Report of an international workshop to standardize response criteria for non-Hodgkin's lymphomas. J Clin Oncol 17:1244. https://doi.org/10.1200/jco.1999.17.4.1244 ID - ref37 ER - TY - STD TI - Cheson BD, Pfistner B, Juweid ME et al (2007) Revised response criteria for malignant lymphoma. J Clin Oncol 25:579–586. https://doi.org/10.1200/jco.2006.09.2403 ID - ref38 ER - TY - STD TI - Meignan M, Gallamini A, Meignan M, Gallamini A, Haioun C (2009) Report on the first international workshop on interim-PET scan in lymphoma. Leuk Lymphoma 50:1257–1260. https://doi.org/10.1080/10428190903040048 ID - ref39 ER - TY - STD TI - Cheson BD, Fisher RI, Barrington SF et al (2014) Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J Clin Oncol 32:3059–3068. https://doi.org/10.1200/jco.2013.54.8800 ID - ref40 ER - TY - STD TI - Cheson BD, Ansell S, Schwartz L et al (2016) Refinement of the Lugano classification lymphoma response criteria in the era of immunomodulatory therapy. Blood 128:2489–2496. https://doi.org/10.1182/blood-2016-05-718528 ID - ref41 ER - TY - STD TI - Younes A, Hilden P, Coiffier B et al (2017) International working group consensus response evaluation criteria in lymphoma (RECIL 2017). Ann Oncol 28:1436–1447. https://doi.org/10.1093/annonc/mdx097 ID - ref42 ER - TY - STD TI - Kong BY, Menzies AM, Saunders CA et al (2016) Residual FDG-PET metabolic activity in metastatic melanoma patients with prolonged response to anti-PD-1 therapy. Pigment Cell Melanoma Res 29:572–577. https://doi.org/10.1111/pcmr.12503 ID - ref43 ER - TY - STD TI - Kaira K, Higuchi T, Naruse I et al (2018) Metabolic activity by 18 F–FDG-PET/CT is predictive of early response after nivolumab in previously treated NSCLC. Eur J Nucl Med Mol Imaging 45:56–66. https://doi.org/10.1007/s00259-017-3806-1 ID - ref44 ER - TY - STD TI - Spigel DR, Chaft JE, Gettinger S et al (2018) FIR: efficacy, safety, and biomarker analysis of a phase II open-label study of atezolizumab in PD-L1–selected patients with NSCLC. J Thorac Oncol 13:1733–1742. https://doi.org/10.1016/j.jtho.2018.05.004 ID - ref45 ER - TY - STD TI - Humbert O, Cadour N, Paquet M et al (2020) 18FDG PET/CT in the early assessment of non-small cell lung cancer response to immunotherapy: frequency and clinical significance of atypical evolutive patterns. Eur J Nucl Med Mol Imaging 47:1158–1167. https://doi.org/10.1007/s00259-019-04573-4 ID - ref46 ER - TY - STD TI - Ansell SM, Lesokhin AM, Borrello I et al (2015) PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma. N Engl J Med 372:311–319. https://doi.org/10.1056/nejmoa1411087 ID - ref47 ER - TY - STD TI - Armand P, Shipp MA, Ribrag V et al (2016) Programmed death-1 blockade with pembrolizumab in patients with classical Hodgkin lymphoma after brentuximab vedotin failure. J Clin Oncol 34:3733–3739. https://doi.org/10.1200/jco.2016.67.3467 ID - ref48 ER - TY - STD TI - Chen R, Zinzani PL, Fanale MA et al (2017) Phase II study of the efficacy and safety of pembrolizumab for relapsed/refractory classic Hodgkin lymphoma. J Clin Oncol 35:2125–2132. https://doi.org/10.1200/jco.2016.72.1316 ID - ref49 ER - TY - STD TI - Armand P, Engert A, Younes A et al (2018) Nivolumab for relapsed/refractory classic Hodgkin lymphoma after failure of autologous hematopoietic cell transplantation: extended follow-up of the multicohort single-arm phase II CheckMate 205 trial. J Clin Oncol 36:1428–1439. https://doi.org/10.1200/jco.2017.76.0793 ID - ref50 ER - TY - STD TI - Moskowitz CH, Zinzani PL, Fanale MA et al (2016) Pembrolizumab in relapsed/refractory classical Hodgkin lymphoma: primary end point analysis of the phase 2 Keynote-087 study. Blood 128:1107–1107 ID - ref51 ER - TY - STD TI - Maruyama D, Hatake K, Kinoshita T et al (2017) Multicenter phase II study of nivolumab in Japanese patients with relapsed or refractory classical Hodgkin lymphoma. Cancer Sci 108:1007–1012. https://doi.org/10.1111/cas.13230 ID - ref52 ER - TY - STD TI - Chan TSY, Luk T-H, Lau JSM, Khong P-L, Kwong Y-L (2017) Low-dose pembrolizumab for relapsed/refractory Hodgkin lymphoma: high efficacy with minimal toxicity. Ann Hematol 96:647–651. https://doi.org/10.1007/s00277-017-2931-z ID - ref53 ER - TY - STD TI - Rossi C, Gilhodes J, Maerevoet M et al (2018) Efficacy of chemotherapy or chemo-anti-PD-1 combination after failed anti-PD-1 therapy for relapsed and refractory hodgkin lymphoma: a series from lysa centers. Am J Hematol 93:1042–1049. https://doi.org/10.1002/ajh.25154 ID - ref54 ER - TY - STD TI - Dercle L, Seban R-D, Lazarovici J et al (2018) 18F-FDG PET and CT scans detect new imaging patterns of response and progression in patients with Hodgkin lymphoma treated by anti–programmed death 1 immune checkpoint inhibitor. J Nucl Med 59:15–24. https://doi.org/10.2967/jnumed.117.193011 ID - ref55 ER - TY - STD TI - Dercle L, Ammari S, Seban R-D et al (2018) Kinetics and nadir of responses to immune checkpoint blockade by anti-PD1 in patients with classical Hodgkin lymphoma. Eur J Cancer 91:136–144. https://doi.org/10.1016/j.ejca.2017.12.015 ID - ref56 ER - TY - STD TI - Mokrane F-Z, Chen A, Schwartz LH et al (2020) Performance of CT compared with 18F-FDG PET in predicting the efficacy of nivolumab in relapsed or refractory Hodgkin lymphoma. Radiology 295:651-661. https://doi.org/10.1148/radiol.2020192056 ID - ref57 ER - TY - STD TI - Chen A, Mokrane F-Z, Schwartz LH et al (2020) Early 18F-FDG PET/CT response predicts survival in relapsed or refractory Hodgkin lymphoma treated with Nivolumab. J Nucl Med 61:649–654. https://doi.org/10.2967/jnumed.119.232827 ID - ref58 ER - TY - STD TI - Castello A, Grizzi F, Qehajaj D, Rahal D, Lutman F, Lopci E (2019) 18F-FDG PET/CT for response assessment in Hodgkin lymphoma undergoing immunotherapy with checkpoint inhibitors. Leuk Lymphoma 60:367–375. https://doi.org/10.1080/10428194.2018.1488254 ID - ref59 ER - TY - STD TI - Shah NN, Nagle SJ, Torigian DA et al (2018) Early positron emission tomography/computed tomography as a predictor of response after CTL019 chimeric antigen receptor –T-cell therapy in B-cell non-Hodgkin lymphomas. Cytotherapy 20:1415–1418. https://doi.org/10.1016/j.jcyt.2018.10.003 ID - ref60 ER - TY - STD TI - Wang J, Hu Y, Yang S et al (2019) Role of fluorodeoxyglucose positron emission tomography/computed tomography in predicting the adverse effects of chimeric antigen receptor t cell therapy in patients with non-Hodgkin lymphoma. Biol Blood Marrow Transplant 25:1092–1098. https://doi.org/10.1016/j.bbmt.2019.02.008 ID - ref61 ER - TY - STD TI - Basler L, Gabryś HS, Hogan SA et al (2020) Radiomics, tumour volume and blood biomarkers for early prediction of pseudoprogression in metastatic melanoma patients treated with immune checkpoint inhibition. Clin Cancer Res. https://doi.org/10.1158/1078-0432.CCR-20-0020 ID - ref62 ER - TY - STD TI - Seith F, Forschner A, Weide B et al (2020) Is there a link between very early changes of primary and secondary lymphoid organs in (18)F-FDG-PET/MRI and treatment response to checkpoint inhibitor therapy? J Immunother Cancer 8:e000656. https://dx.doi.org/10.1136%2Fjitc-2020-000656 UR - https://dx.doi.org/10.1136%2Fjitc-2020-000656 ID - ref63 ER - TY - STD TI - Cousin S, Italiano A (2016) Molecular pathways: immune checkpoint antibodies and their toxicities. Clin Cancer Res 22:4550–4555 ID - ref64 ER - TY - STD TI - Nishijima TF, Shachar SS, Nyrop KA, Muss HB (2017) Safety and tolerability of PD-1/PD-L1 inhibitors compared with chemotherapy in patients with advanced cancer: a meta-analysis. Oncologist 22:470. https://doi.org/10.1634/theoncologist.2016-0419 ID - ref65 ER - TY - STD TI - Khoja L, Day D, Wei-Wu Chen T, Siu L, Hansen A (2017) Tumour-and class-specific patterns of immune-related adverse events of immune checkpoint inhibitors: a systematic review. Ann Oncol 28:2377–2385. https://doi.org/10.1093/annonc/mdx286 ID - ref66 ER - TY - STD TI - Foppen MHG, Rozeman EA, van Wilpe S et al (2018) Immune checkpoint inhibition-related colitis: symptoms, endoscopic features, histology and response to management. ESMO open 3:e000278. https://doi.org/10.1136/esmoopen-2017-000278 ID - ref67 ER - TY - STD TI - Fujii T, Colen RR, Bilen MA et al (2018) Incidence of immune-related adverse events and its association with treatment outcomes: the MD Anderson Cancer Center experience. Investig New Drugs 36:638–646. https://doi.org/10.1007/s10637-017-0534-0 ID - ref68 ER - TY - STD TI - Rossi S, Toschi L, Castello A, Grizzi F, Mansi L, Lopci E (2017) Clinical characteristics of patient selection and imaging predictors of outcome in solid tumours treated with checkpoint-inhibitors. Eur J Nucl Med Mol Imaging 44:2310–2325. https://doi.org/10.1007/s00259-017-3802-5 ID - ref69 ER - TY - STD TI - Tsai KK, Pampaloni MH, Hope C et al (2016) Increased FDG avidity in lymphoid tissue associated with response to combined immune checkpoint blockade. J Immunother Cancer 4:58. https://doi.org/10.1186/s40425-016-0162-9 ID - ref70 ER - TY - STD TI - Wachsmann JW, Ganti R, Peng F (2017) Immune-mediated disease in ipilimumab immunotherapy of melanoma with FDG PET-CT. Acad Radiol 24:111–115. https://doi.org/10.1016/j.acra.2016.08.005 ID - ref71 ER - TY - STD TI - Nobashi T, Baratto L, Reddy SA et al (2019) Predicting response to immunotherapy by evaluating tumours, lymphoid cell-rich organs, and immune-related adverse events using FDG-PET/CT. Clin Nucl Med 44:e272–e279. https://doi.org/10.1097/rlu.0000000000002453 ID - ref72 ER - TY - STD TI - Haratani K, Hayashi H, Chiba Y et al (2018) Association of immune-related adverse events with nivolumab efficacy in non–small-cell lung cancer. JAMA Oncol 4:374–378. https://doi.org/10.1001/jamaoncol.2017.2925 ID - ref73 ER - TY - STD TI - Aide N, Hicks RJ, Le Tourneau C, Lheureux S, Fanti S, Lopci E (2019) FDG PET/CT for assessing tumour response to immunotherapy. Eur J Nucl Med Mol Imaging 46:238–250. https://doi.org/10.1007/s00259-018-4171-4 ID - ref74 ER - TY - STD TI - Nishino M, Hatabu H, Hodi FS (2019) Imaging of cancer immunotherapy: current approaches and future directions. Radiology 290:9–22. https://doi.org/10.1148/radiol.2018181349 ID - ref75 ER - TY - STD TI - Brudno JN, Kochenderfer JN (2016) Toxicities of chimeric antigen receptor T cells: recognition and management. Blood 127:3321–3330. https://doi.org/10.1182/blood-2016-04-703751 ID - ref76 ER - TY - STD TI - Neelapu SS, Tummala S, Kebriaei P et al (2018) Chimeric antigen receptor T-cell therapy — assessment and management of toxicities. Nat Rev Clin Oncol 15:47–62. https://doi.org/10.1038/nrclinonc.2017.148 ID - ref77 ER - TY - STD TI - Hu Y, Wang J, Pu C et al (2018) Delayed terminal ileal perforation in a relapsed/refractory B-cell lymphoma patient with rapid remission following chimeric antigen receptor T-cell therapy. Cancer Res Treat 50:1462–1466. https://doi.org/10.4143/crt.2017.473 ID - ref78 ER - TY - STD TI - Wang Y, Zhang W-y, Han Q-w et al (2014) Effective response and delayed toxicities of refractory advanced diffuse large B-cell lymphoma treated by CD20-directed chimeric antigen receptor-modified T cells. Clin Immunol 155:160-175. https://doi.org/10.1016/j.clim.2014.10.002 ID - ref79 ER - TY - STD TI - Cohen AD, Garfall AL, Stadtmauer EA et al (2019) B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma. J Clin Invest 129:2210–2221. https://doi.org/10.1172/jci126397 ID - ref80 ER - TY - STD TI - Raje N, Berdeja J, Lin Y et al (2019) Anti-BCMA CAR T-cell therapy bb2121 in relapsed or refractory multiple myeloma. N Engl J Med 380:1726–1737. https://doi.org/10.1056/nejmoa1817226 ID - ref81 ER - TY - STD TI - Fry TJ, Shah NN, Orentas RJ et al (2018) CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy. Nat Med 24:20–28. https://doi.org/10.1038/nm.4441 ID - ref82 ER - TY - STD TI - Titov A, Valiullina A, Zmievskaya E et al (2020) Advancing CAR T-cell therapy for solid tumours: lessons learned from lymphoma treatment. Cancers (Basel) 12:125. https://doi.org/10.3390/cancers12010125 ID - ref83 ER - TY - STD TI - Bachmann M (2019) The UniCAR system: a modular CAR T cell approach to improve the safety of CAR T cells. Immunol Lett 211:13–22. https://doi.org/10.1016/j.imlet.2019.05.003 ID - ref84 ER - TY - STD TI - Lee YG, Marks I, Srinivasarao M et al (2019) Use of a single CAR T cell and several bispecific adapters facilitates eradication of multiple antigenically different solid tumours. Cancer Res 79:387–396. https://doi.org/10.1158/0008-5472.can-18-1834 ID - ref85 ER - TY - STD TI - Minutolo NG, Hollander EE, Powell DJ Jr (2019) The emergence of universal immune receptor T cell therapy for cancer. Front Oncol 9:176. https://doi.org/10.3389/fonc.2019.00176 ID - ref86 ER - TY - STD TI - Liu E, Marin D, Banerjee P et al (2020) Use of CAR-transduced natural killer cells in CD19-positive lymphoid tumours. N Engl J Med 382:545–553. https://doi.org/10.1056/nejmoa1910607 ID - ref87 ER - TY - STD TI - Natarajan A, Mayer AT, Reeves RE, Nagamine CM, Gambhir SS (2017) Development of novel immunoPET tracers to image human PD-1 checkpoint expression on tumour-infiltrating lymphocytes in a humanized mouse model. Mol Imaging Biol 19:903–914. https://doi.org/10.1007/s11307-017-1060-3 ID - ref88 ER - TY - STD TI - Natarajan A, Mayer AT, Xu L, Reeves RE, Gano J, Gambhir SS (2015) Novel radiotracer for immunoPET imaging of PD-1 checkpoint expression on tumour infiltrating lymphocytes. Bioconjug Chem 26:2062–2069. https://doi.org/10.1021/acs.bioconjchem.5b00318 ID - ref89 ER - TY - STD TI - Verhoeff SR, van den Heuvel MM, van Herpen CM, Piet B, Aarntzen EH, Heskamp S (2020) Programmed cell Death-1/Ligand-1 PET imaging: a novel tool to optimize immunotherapy? PET Clin 15:35–43. https://doi.org/10.1016/j.cpet.2019.08.008 ID - ref90 ER - TY - STD TI - Bensch F, van der Veen EL, Lub-de Hooge MN et al (2018) 89Zr-atezolizumab imaging as a non-invasive approach to assess clinical response to PD-L1 blockade in cancer. Nat Med 24:1852–1858. https://doi.org/10.1038/s41591-018-0255-8 ID - ref91 ER - TY - STD TI - Niemeijer A, Leung D, Huisman M et al (2018) Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer. Nat Commun 9:4664. https://doi.org/10.1038/s41467-018-07131-y ID - ref92 ER - TY - STD TI - Gibson HM, McKnight BN, Malysa A et al (2018) IFNγ PET imaging as a predictive tool for monitoring response to tumour immunotherapy. Cancer Res 78:5706–5717. https://doi.org/10.1158/0008-5472.can-18-0253 ID - ref93 ER - TY - STD TI - Larimer BM, Wehrenberg-Klee E, Dubois F et al (2017) Granzyme B PET imaging as a predictive biomarker of immunotherapy response. Cancer Res 77:2318–2327. https://doi.org/10.1158/0008-5472.can-16-3346 ID - ref94 ER - TY - STD TI - Markovic SN, Galli F, Suman VJ et al (2018) Non-invasive visualization of tumour infiltrating lymphocytes in patients with metastatic melanoma undergoing immune checkpoint inhibitor therapy: a pilot study. Oncotarget 9:30268-30278. https://doi.org/10.18632/oncotarget.25666 ID - ref95 ER - TY - STD TI - Ting DS, Liu Y, Burlina P, Xu X, Bressler NM, Wong TY (2018) AI for medical imaging goes deep. Nat Med 24:539–540. https://doi.org/10.1038/s41591-018-0029-3 ID - ref96 ER - TY - STD TI - Wu M, Zhang Y, Zhang Y, Liu Y, Wu M, Ye Z (2019) Imaging-based biomarkers for predicting and evaluating cancer immunotherapy response. Radiol Imag Cancer 1:e190031. https://doi.org/10.1148/rycan.2019190031 ID - ref97 ER -