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Fig. 5 | European Radiology Experimental

Fig. 5

From: Ultra-high-field 7-T MRI in multiple sclerosis and other demyelinating diseases: from pathology to clinical practice

Fig. 5

Distinguishing multiple sclerosis (MS) from neuromyelitis optica (NMO) lesions. In the upper row, a patient with multiple sclerosis, from left to right: axial T2-weighted image (T2) with a hyperintense lesion (white arrow) traversed by an ill-defined central venule; the same lesion appears hypointense on a T1-weighted magnetisation-prepared rapid gradient echo image (T1), with hypointense peripheral rim and iso-to-hypointense central core traversed by a well-defined venule on a gradient-echo T2*-weighted image (GRE-T2*), and hyperintense on quantitative susceptibility mapping (QSM). Hypointense signal intensity within the lesion on T2*-weighted image and hyperintensity on QSM suggest iron accumulation. In the lower row, a patient with NMO, from left to right: axial T2-weighted image with two round hyperintense lesions (white arrows); the same lesions appear hypointense on T1, hyperintense on GRE-T2*, and isointense on QSM, thus inconspicuous with iron accumulation. The scale bar is for the QSM image with units of parts per billion. Published with permission from AJNR Am J Neuroradiol [74]

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