Cord cross-sectional area at foramen magnum as a correlate of disability in amyotrophic lateral sclerosis

European Radiology Experimental

Table 1 Demographics and magnetic resonance imaging results

	Patients with ALS	Healthy control subjects	p Value
Subjects, total (males/females)	23 (13/10)	18 (5/13)	–
Age, years, mean ± SD	61.7 ± 10.3	55.7 ± 10.2	0.738
FMCA, mm², mean ± SD	78.3 ± 9.9	88.9 ± 6.0	< 0.005^a
BPF, mean ± SD	0.78 ± 0.06	0.79 ± 0.06	0.336
ALSFRS-R, median; range	39; 27–46	–	–
Disease duration, months, mean ± SD	9.43 ± 6.41	–	–

Abbreviations: ALS Amyotrophic lateral sclerosis; FMCA Foramen magnum cord area; BPF Brain parenchymal fraction; ALSFRS-R ALS Functional Rating Scale–Revised
^a Corrected for multiple comparisons with Bonferroni post hoc test