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Fig. 3 | European Radiology Experimental

Fig. 3

From: Radiomics of liver MRI predict metastases in mice

Fig. 3

Representative histological images of mouse livers (H&E staining). RML right median lobe, GB gall bladder, LML left median lobe, LLL left lateral lobe, CL caudate lobe, RL right inferior and superior lobe. Orange squares mark the area of 40× magnification for the respective images below. a Overview of mouse liver with control PBS injection, harvested at day 20. Overview in 1.25× magnification shows complete transversal section of the liver covering RML, GB, LML, LLL, and the bifid CL. 10× magnification and 40× magnification show intact liver parenchyma without any signs of tumor invasion. b Overview of a mouse liver harvested on day 8 after non-selective intraportal injection of syngeneic MC38 tumor cells. While no tumor can be detected macroscopically and in the overview of the specimen, 10× and 40× magnification reveal small nests of intraparenchymal and paravascular tumor cells, accompanied by infiltrating leukocytes. c Overview of mouse liver harvested on day 20 after non-selective intraportal injection of syngeneic MC38 tumor cells. Multiple tumor nodules can be appreciated already at a macroscopic level in all liver lobes

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