Fig. 7
From: Photoacoustic imaging of tumour vascular permeability with indocyanine green in a mouse model
Normalisation of ICG-photoacoustic signals in tumours with a VEGF-blocking agent. a Representative photoacoustic imaging with B-mode images show prevention of ICG vascular leakage in subcutaneous LLC tumours with anti-VEGF therapy. The colour map has red gradation that fades into blue (n = 4, ICG: 5 mg/ml). b Graph showing maximum photoacoustic signal values of subcutaneous LLC tumours with or without anti-VEGF therapy (p < 0.001; n = 4, ICG: 5 mg/ml). c Growth curves of subcutaneous LLC tumours in mice treated with control saline (black circle) and VEGF-trap (red triangle, 5 mg/kg). Data shown are means ± SD. Treatment and imaging schedules are indicated with arrows (n = 4, ICG 5 mg/ml). ***p < 0.001