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Fig. 6 | European Radiology Experimental

Fig. 6

From: Photoacoustic imaging of tumour vascular permeability with indocyanine green in a mouse model

Fig. 6

Extravasation of ICG into the interstitial space surrounding tumour vasculature. a Immunofluorescence staining (original magnification, 40×) of LLC tumour sections demonstrating ICG accumulation at different doses (1, 2.5 and 5 mg/ml; pseudo-red colour) surrounding CD31+ tumour capillaries (green, white arrowheads) of LLC tumours 30 s after intravenous administration. Nuclei were counterstained with 4′,6-diamidino-2-phenylindole (blue). Scale bar: 20 μm. b Confocal fluorescence imaging of LLC tumour sections (original magnification, 60×). Note that ICG (5 mg/ml) was distributed extensively in the tumour cells, but not in CD31+ tumour capillaries (yellow arrowheads)

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