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Table 1 Summary of the different MHC mismatch combination types, time intervals between transplantation and MRI examination/tissue explantation, number of CAF cases examined for each mice group and mean acute rejection scores in the adopted experimental settings

From: Magnetisation transfer as a biomarker for chronic airway fibrosis in a mouse lung transplantation model

Type of MHC mismatch combination

Time between transplantation and explantation (weeks)

Chronic airway fibrosis (n)/animals examined (n)

Acute rejection score based on ISHLT guidelinesa of all CAF and no-CAF mice (A1–A4, mean ± SD)

Major

(D:BALB/c; R:C57BL/6)

8

3/5

3.80 ± 0.27

Minor

(D:C57BL/10; R:C57BL/6)

8

2/10

1.73 ± 1.38

Minor

(D:C57BL/10; R:C57BL/6)

12

1/7

2.71 ± 0.95

Minor

(D:C57BL/6; R:C57BL/10)

8

1/2

2.75 ± 1.06

  1. aISHLT guidelines [3]
  2. D donor, R recipient